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Cellosaurus BICR 6 (CVCL_2314)

[Text version]
Cell line name BICR 6
Synonyms BICR-6; BICR6; Beatson Institute for Cancer Research 6
Accession CVCL_2314
Resource Identification Initiative To cite this cell line use: BICR 6 (RRID:CVCL_2314)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:02,30:02
HLA-BB*07:02,18:01
HLA-CC*05:01,07:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African4.56
Native American0
East Asian, North5.39
East Asian, South0
South Asian0
European, North53.16
European, South36.88
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC=05070501

Markers:
AmelogeninX,Y
CSF1PO10
D5S81812
D7S82010
D13S31714
D16S53911
TH016
TPOX9,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=8390283; DOI=10.1038/bjc.1993.238; PMCID=PMC1968513
Julie E. Burns, M.C. Baird, Louise J. Clark, Philip A. Burns, Kirsten Gilian Edington, Charlotte Chapman, Roy Mitchell, Gordon Robertson, David Soutar, Eric Kenneth Parkinson;
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Br. J. Cancer 67:1274-1284(1993)

PubMed=7646764; DOI=10.1002/mc.2940130408
Kirsten Gilian Edington, Oonagh P. Loughran, Isabella J. Berry, Eric Kenneth Parkinson;
Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.
Mol. Carcinog. 13:254-265(1995)

PubMed=9150362; DOI=10.1038/sj.onc.1201028
Oonagh P. Loughran, Louise J. Clark, Jacquelyn Bond, Angela Baker, Isabella J. Berry, Kirsten Gilian Edington, I.-S. Ly, R. Simmons, Robin Haw, Donald M. Black, Robert F. Newbold, Eric Kenneth Parkinson;
Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.
Oncogene 14:1955-1964(1997)

PubMed=10523844; DOI=10.1038/sj.onc.1202957
Mahima Agochiya, Valerie G. Brunton, Dewi W. Owens, Eric Kenneth Parkinson, Christos Paraskeva, W. Nicol Keith, Margaret Catherine Frame;
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.
Oncogene 18:5646-5653(1999)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections (Providers) CancerTools; 152848
ECACC; 05070501 - Discontinued
Ximbio; 152848
Cell line databases/resources cancercelllines; CVCL_2314
Cell_Model_Passport; SIDM01517
DepMap; ACH-000415
Biological sample resources BioSample; SAMN10987690
CRISP screens repositories BioGRID_ORCS_Cell_line; 712
Chemistry resources PharmacoDB; BICR6_99_2019
Encyclopedic resources Wikidata; Q54796533
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM886888
GEO; GSM887953
Polymorphism and mutation databases Cosmic; 848753
IARC_TP53; 1908
LiGeA; CCLE_750
Progenetix; CVCL_2314
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number32