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Cellosaurus BICR 10 (CVCL_2307)

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Cell line name BICR 10
Synonyms BICR-10; BICR10; BICR-10 R; Beatson Institute for Cancer Research 10
Accession CVCL_2307
Resource Identification Initiative To cite this cell line use: BICR 10 (RRID:CVCL_2307)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Karyotypic information: Near diploid karyotype (PubMed=31321735).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Oral cavity, buccal mucosa; UBERON=UBERON_0006956.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,01:01
HLA-BB*14:01,44:02
HLA-CC*01:02,07:06
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.05
Native American0
East Asian, North0.01
East Asian, South0
South Asian0.82
European, North71.25
European, South27.87
Disease Buccal mucosa squamous cell carcinoma (NCIt: C4040)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1290724; ECACC=04072103; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12,14
D3S135817
D5S81811,13
D7S82011,12
D8S117913,14
D13S3178,14
D16S5399,13
D18S5114,19
D21S1130.2,32.2
FGA21,22
Penta D9,12
Penta E7,18
TH019.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=8390283; DOI=10.1038/bjc.1993.238; PMCID=PMC1968513
Julie E. Burns, M.C. Baird, Louise J. Clark, Philip A. Burns, Kirsten Gilian Edington, Charlotte Chapman, Roy Mitchell, Gordon Robertson, David Soutar, Eric Kenneth Parkinson;
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Br. J. Cancer 67:1274-1284(1993)

PubMed=7646764; DOI=10.1002/mc.2940130408
Kirsten Gilian Edington, Oonagh P. Loughran, Isabella J. Berry, Eric Kenneth Parkinson;
Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.
Mol. Carcinog. 13:254-265(1995)

PubMed=9307265
Fiona McGregor, Eric Wagner, David H. Felix, David Soutar, Eric Kenneth Parkinson, Paul Robert Harrison;
Inappropriate retinoic acid receptor-beta expression in oral dysplasias: correlation with acquisition of the immortal phenotype.
Cancer Res. 57:3886-3889(1997)

PubMed=10523844; DOI=10.1038/sj.onc.1202957
Mahima Agochiya, Valerie G. Brunton, Dewi W. Owens, Eric Kenneth Parkinson, Christos Paraskeva, W. Nicol Keith, Margaret Catherine Frame;
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.
Oncogene 18:5646-5653(1999)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31321735; DOI=10.1007/s13258-019-00850-6
Ilda Patricia Ribeiro, Joana M. Rodrigues, Alexandra Mascarenhas, Vanessa Marques, Francisco Caramelo, Maria J. Juliao, Thomas Liehr, Joana Barbosa Melo, Isabel Marques Carreira;
(Cyto)genomic and epigenetic characterization of BICR 10 cell line and three new established primary human head and neck squamous cell carcinoma cultures.
Genes Genomics 41:1207-1221(2019)

PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259
Annie Wai-Yeeng Chai, Pei-San Yee, Stacey Price, Shi-Mun Yee, Hui-Mei Lee, Vivian K.H. Tiong, Emanuel Goncalves, Fiona M. Behan, Jessica Bateson, James G.R. Gilbert, Aik-Choon Tan ...Show all 14 authors... , Ultan McDermott, Mathew J. Garnett, Sok-Ching Cheong; Show fewer authors
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.
eLife 9:e57761.1-e57761.34(2020)

Cross-references
Cell line collections (Providers) CancerTools; 152841
ECACC; 04072103 - Discontinued
Ximbio; 152841
Cell line databases/resources CLO; CLO_0009941
cancercelllines; CVCL_2307
Cell_Model_Passport; SIDM00077
Cosmic-CLP; 1290724
DepMap; ACH-001331
LINCS_LDP; LCL-1203
Biological sample resources BioSample; SAMN03473143
CRISP screens repositories BioGRID_ORCS_Cell_line; 835
Chemistry resources GDSC; 1290724
PharmacoDB; BICR10_93_2019
Encyclopedic resources Wikidata; Q54796517
Experimental variables resources EFO; EFO_0006540
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM827321
GEO; GSM1669621
Polymorphism and mutation databases Progenetix; CVCL_2307
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number34