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Cellosaurus 1.2B4 (CVCL_2258)

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Cell line name 1.2B4
Accession CVCL_2258
Resource Identification Initiative To cite this cell line use: 1.2B4 (RRID:CVCL_2258)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-3524.
Characteristics: Insulin secreting.
Characteristics: Produced by electrofusion of HuP-T3 with a primary culture of human pancreatic islets.
Doubling time: ~20 hours (ECACC=10070103).
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Lys1358fs*2 (c.4071_4072insGATT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1299 (HuP-T3)
Category Hybrid cell line
STR profile Source(s): ECACC=10070103; Patent=US20040005702

Markers:
AmelogeninX,Y
CSF1PO10
D3S135815,16
D5S81810,14
D7S82012
D8S117915
D13S3179,11
D16S53910,13
D18S5116,17
D21S1128,30
FGA21,22
TH019
TPOX8,12
vWA18

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Publications

Patent=US20040005702
Peter R. Flatt, Neville H. McClenaghan;
Insulin producing cell-line.
Patent number US20040005702, 08-Jan-2004

Cross-references
Cell line collections (Providers) CancerTools; 161633
ECACC; 10070103
Encyclopedic resources Wikidata; Q54399845
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number16