Cellosaurus logo
expasy logo

Cellosaurus HLF-a (CVCL_2255)

[Text version]
Cell line name HLF-a
Synonyms HLFa; HLFA
Accession CVCL_2255
Resource Identification Initiative To cite this cell line use: HLF-a (RRID:CVCL_2255)
Comments Problematic cell line: Misclassified. Originally thought to be a lung squamous cell carcinoma cell line but using a variety of omics methods was shown to be a fibroblastic cell line (DOI=10.1101/166199; DepMap=ACH-000797).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: African American.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Genome ancestry Source: PubMed=30894373

Origin% genome
African90.86
Native American0
East Asian, North2.07
East Asian, South0
South Asian0
European, North1.99
European, South5.07
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 54Y
Category Undefined cell line type
STR profile Source(s): ATCC=CCL-199

Markers:
AmelogeninX
CSF1PO10,11
D2S133818,25
D3S135815
D5S8188,12
D7S8209,12
D8S117913,15
D13S31711,12
D16S53912,13
D18S5116,17
D19S43314,14.2
D21S1129,34
FGA19
Penta D7,11
Penta E8,9
TH016,9.3
TPOX6,8
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222
Robert J. Hay, Carolyn D. Williams, Marvin L. Macy, Kantharajapura Subbegowda Lavappa;
Cultured cell lines for research on pulmonary physiology available through the American Type Culture Collection.
Am. Rev. Respir. Dis. 125:222-232(1982)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24002593; DOI=10.1038/bjc.2013.452; PMCID=PMC3776976
D. Wu, Yi Pang, Matthew D. Wilkerson, D. Wang, Peter S. Hammerman, Jun S. Liu;
Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.
Br. J. Cancer 109:1599-1608(2013)

DOI=10.1101/166199
Antoine de Weck, Hans Bitter, Audrey Kauffmann;
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CCL-199
ECACC; 90112703 - Discontinued
Cell line databases/resources CLO; CLO_0003783
CLDB; cl1699
cancercelllines; CVCL_2255
Cell_Model_Passport; SIDM01710
DepMap; ACH-000797
Biological sample resources BioSample; SAMN03471463
BioSample; SAMN10988274
Chemistry resources PharmacoDB; HLFa_550_2019
Encyclopedic resources Wikidata; Q54889851
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM206505
GEO; GSM274805
GEO; GSM274806
GEO; GSM887085
GEO; GSM888155
Polymorphism and mutation databases IARC_TP53; 30040
LiGeA; CCLE_508
Progenetix; CVCL_2255
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number29