Cellosaurus logo
expasy logo

Cellosaurus C-4-I (CVCL_2253)

[Text version]
Cell line name C-4-I
Synonyms C-4I; C-4 I; C-4-i; C4-I; C4-1; C4 I; C4I; C41; Hs 636.T; Hs 636 T
Accession CVCL_2253
Resource Identification Initiative To cite this cell line use: C-4-I (RRID:CVCL_2253)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Virology: Contains a complete HPV18 genome.
Doubling time: 2 days (PubMed=29156801).
Microsatellite instability: Stable (MSS) (PubMed=12661003; Sanger).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
HLA typing Source: PubMed=77569
Class I
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.73
East Asian, North0
East Asian, South0
South Asian1.02
European, North72.49
European, South25.76
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1095 ! C-4-II
Sex of cell Female
Age at sampling 41Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1594; Cosmic-CLP=687506; DepMap=ACH-001334; PubMed=29156801

Penta D9,13
Penta E19

Run an STR similarity search on this cell line

PubMed=13863218; DOI=10.1093/jnci/28.3.605
Auersperg N., Hawryluk A.P.
Chromosome observations on three epithelial-cell cultures derived from carcinomas of the human cervix.
J. Natl. Cancer Inst. 28:605-627(1962)

PubMed=14114965; DOI=10.1093/jnci/32.1.135
Auersperg N.
Long-term cultivation of hypodiploid human tumor cells.
J. Natl. Cancer Inst. 32:135-163(1964)

PubMed=5796380; DOI=10.1093/jnci/43.1.151
Auersperg N.
Histogenetic behavior of tumors. I. Morphologic variation in vitro and in vivo of two related human carcinoma cell lines.
J. Natl. Cancer Inst. 43:151-173(1969)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

Herz F., Miller O.J., Miller D.A., Auersperg N., Koss L.G.
Chromosome analysis and alkaline phosphatase of C41, a cell line of human cervical origin distinct from HeLa.
Cancer Res. 37:3209-3213(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x
Espmark J.A., Ahlqvist-Roth L., Sarne L., Persson A.
Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.
Tissue Antigens 11:279-286(1978)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=2983228; DOI=10.1038/314111a0
Schwarz E., Freese U.-K., Gissmann L., Mayer W., Roggenbuck B., Stremlau A., zur Hausen H.
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells.
Nature 314:111-114(1985)

Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3029760; DOI=10.1073/pnas.84.4.1070
Durst M., Croce C.M., Gissmann L., Schwarz E., Huebner K.
Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.
Proc. Natl. Acad. Sci. U.S.A. 84:1070-1074(1987)

PubMed=12661003; DOI=10.1002/gcc.10196
Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U., Santibanez-Koref M.F., Schlag P.M., Scherneck S.
Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.
Genes Chromosomes Cancer 37:29-35(2003)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35692560; DOI=10.1080/23723556.2022.2078628
de Lourdes Zuniga-Martinez M., Lopez-Mendoza C.M., Tenorio-Salazar J., Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.
Establishment, authenticity, and characterization of cervical cancer cell lines.
Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections (Providers) ATCC; CRL-1594
ATCC; CRL-7396 - Discontinued
ECACC; 89051702
Cell line databases/resources CLO; CLO_0002125
CLO; CLO_0002129
CLDB; cl521
cancercelllines; CVCL_2253
Cell_Model_Passport; SIDM00905
Cosmic-CLP; 687506
DepMap; ACH-001334
Anatomy/cell type resources BTO; BTO:0006016
Biological sample resources BioSample; SAMN03471401
Chemistry resources GDSC; 687506
PharmacoDB; C4I_151_2019
Encyclopedic resources Wikidata; Q54799744
Experimental variables resources EFO; EFO_0002122
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-3610
GEO; GSM113860
GEO; GSM253295
GEO; GSM675731
GEO; GSM685438
GEO; GSM1669639
Polymorphism and mutation databases Cosmic; 687506
Cosmic; 925358
Cosmic; 928906
Cosmic; 877471
Cosmic; 1019308
Cosmic; 1131518
Cosmic; 1193035
Cosmic; 1201771
Cosmic; 2646656
Cosmic; 2660189
Cosmic; 2816213
Progenetix; CVCL_2253
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number35