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Cellosaurus UPCI-SCC-154 (CVCL_2230)

[Text version]
Cell line name UPCI-SCC-154
Synonyms UPCI:SCC154; UPCISCC154; SCC154
Accession CVCL_2230
Resource Identification Initiative To cite this cell line use: UPCI-SCC-154 (RRID:CVCL_2230)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 3.8 days (PubMed=29156801); ~50-60 hours (DSMZ=ACC-669).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3241; DepMap=ACH-001229; DSMZ=ACC-669; PubMed=29156801; PubMed=33802339

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133825
D3S135815,16 (DSMZ=ACC-669)
16 (DepMap=ACH-001229; PubMed=33802339)
D5S81811,12
D7S8209,10
D8S117912
D13S3179,12
D16S53913
D18S5115
D19S43315.2,16 (PubMed=33802339)
16 (DSMZ=ACC-669)
D21S1128,29
FGA20,24
Penta D11,13
Penta E5,14
TH017
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001; PMCID=PMC2025692
Jason S. White, Joel L. Weissfeld, Camille C.R. Ragin, Karen M. Rossie, Christa Lese Martin, Michele Shuster, Chandramohan S. Ishwad, John C. Law, Eugene Nicholas Myers, Jonas T. Johnson, Susanne M. Gollin;
The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.
Oral Oncol. 43:701-712(2007)

PubMed=24403267; DOI=10.1002/cam4.151; PMCID=PMC3892398
Hisato Kawakami, Isamu Okamoto, Kyoichi Terao, Kazuko Sakai, Minoru Suzuki, Shinya Ueda, Kaoru Tanaka, Kiyoko Kuwata, Yume Morita, Koji Ono, Kazuto Nishio ...Show all 14 authors... , Yasumasa Nishimura, Katsumi Doi, Kazuhiko Nakagawa; Show fewer authors
Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma.
Cancer Med. 2:933-941(2013)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28236344; DOI=10.1002/hed.24729; PMCID=PMC5392184
Heather M. Walline, Christine Marie Goudsmit, Jonathan B. McHugh, Alice L. Tang, John Henry Owen, Bin Tean Teh, Erin L. McKean, Thomas W. Glover, Martin P. Graham, Mark Edward P. Prince, Douglas Brian Chepeha ...Show all 19 authors... , Steven B. Chinn, Robert Louis Ferris, Susanne M. Gollin, Thomas K. Hoffmann, Henning Bier, Ruud H. Brakenhoff, Carol R. Bradford, Thomas E. Carey; Show fewer authors
University of Michigan Head and Neck Specialized Program of Research Excellence (SPORE) Program
Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.
Head Neck 39:840-852(2017)

PubMed=28476783; DOI=10.21873/anticanres.11555
Jan Hagemann, Christian Jacobi, Moritz Hahn, Vanessa Schmid, Christian Welz, Sabina Schwenk-Zieger, Roland H. Stauber, Philipp Baumeister, Sven Becker;
Spheroid-based 3D cell cultures enable personalized therapy testing and drug discovery in head and neck cancer.
Anticancer Res. 37:2201-2210(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=33802339; DOI=10.3390/cancers13051069; PMCID=PMC7959143
Eva-Leonne Gottgens, Marleen Ansems, William P.J. Leenders, Johan Bussink, Paul N. Span;
Genotyping and characterization of HPV status, hypoxia, and radiosensitivity in 22 head and neck cancer cell lines.
Cancers (Basel) 13:1069.1-1069.12(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-3241
DSMZ; ACC-669
IZSLER; BS TCL 245
Cell line databases/resources DepMap; ACH-001229
DSMZCellDive; ACC-669
Biological sample resources BioSample; SAMN03473423
Encyclopedic resources Wikidata; Q54991687
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25