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Cellosaurus SK-GT-4 (CVCL_2195)

[Text version]

Cell line name SK-GT-4
Synonyms SKGT4; SK4
Accession CVCL_2195
Resource Identification Initiative To cite this cell line use: SK-GT-4 (RRID:CVCL_2195)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Population: Caucasian.
Doubling time: 39 hours (PubMed=8334620); ~30-35 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis.
Caution: TP53 mutation indicated incorrectly as being at p.Arg175His (c.524G>A) in PubMed=7665247.
Misspelling: SJGT4; In GEO GSM337727.
Derived from sampling site: Esophagus; distal.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (PubMed=27594985; Cosmic-CLP; DepMap).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln100Ter (c.298C>T); ClinVar=VCV000634707; Zygosity=Homozygous (PubMed=20075370; Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American1.08
East Asian, North1.62
East Asian, South0
South Asian7.99
European, North27.72
European, South59.48
Disease Esophageal adenocarcinoma (NCIt: C4025)
Adenocarcinoma of the esophagus (ORDO: Orphanet_99976)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C0X0 (SK4-Rf )
Sex of cell Male
Age at sampling 89Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; DSMZ; PubMed=20075370

Penta D9
Penta E7

Run an STR similarity search on this cell line

PubMed=8334620; DOI=10.1002/1097-0142(19930801)72:3<649::AID-CNCR2820720305>3.0.CO;2-L
Altorki N., Schwartz G.K., Blundell M., Davis B.M., Kelsen D.P., Albino A.P.
Characterization of cell lines established from human gastric-esophageal adenocarcinomas. Biologic phenotype and invasion potential.
Cancer 72:649-657(1993)

PubMed=7665247; DOI=10.1002/ijc.2910640109
Nabeya Y., Loganzo F. Jr., Maslak P., Lai L., de Oliveira A.R., Schwartz G.K., Blundell M.L., Altorki N.K., Kelsen D.P., Albino A.P.
The mutational status of p53 protein in gastric and esophageal adenocarcinoma cell lines predicts sensitivity to chemotherapeutic agents.
Int. J. Cancer 64:37-46(1995)

PubMed=11520067; DOI=10.1006/bbrc.2001.5400
Kan T., Shimada Y., Sato F., Maeda M., Kawabe A., Kaganoi J.-I., Itami A., Yamasaki S., Imamura M.
Gene expression profiling in human esophageal cancers using cDNA microarray.
Biochem. Biophys. Res. Commun. 286:792-801(2001)

PubMed=20075370; DOI=10.1093/jnci/djp499
Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P., Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K., Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H., Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=20139130; DOI=10.1093/carcin/bgq036
Duggan S.P., Behan F.M., Kirca M., Smith S.M., Reynolds J.V., Long A., Kelleher D.P.
An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels.
Carcinogenesis 31:936-945(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

PubMed=26317542; DOI=10.18632/oncotarget.4540
Chen Q.-R., Song S.-M., Wei S.-Z., Liu B., Honjo S., Scott A., Jin J.-K., Ma L., Zhu H.-T., Skinner H.D., Johnson R.L., Ajani J.A.
ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer.
Oncotarget 6:25883-25896(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27594985; DOI=10.12688/f1000research.7033.1
Contino G., Eldridge M.D., Secrier M., Bower L., Elliott R.F., Weaver J., Lynch A.G., Edwards P.A.W., Fitzgerald R.C.
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.
F1000Research 5:1336-1336(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections DSMZ; ACC-712
ECACC; 11012007
Cell line databases/resources Cell_Model_Passport; SIDM00483
Cosmic-CLP; 1503365
DepMap; ACH-001654
DSMZCellDive; ACC-712
Biological sample resources BioSample; SAMN03473395
Chemistry resources GDSC; 1503365
PharmacoDB; SKGT4_1389_2019
Encyclopedic resources Wikidata; Q54953662
Experimental variables resources EFO; EFO_0001237
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSE2144
GEO; GSE13376
GEO; GSM1374878
GEO; GSM1670431
Polymorphism and mutation databases Cosmic; 1599346
IARC_TP53; 4079
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number30