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Cellosaurus SiSo (CVCL_2193)

[Text version]
Cell line name SiSo
Synonyms SISO
Accession CVCL_2193
Resource Identification Initiative To cite this cell line use: SiSo (RRID:CVCL_2193)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 24 hours (PubMed=21556646); ~35 hours (DSMZ=ACC-327).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (Cosmic-CLP=1240212; DepMap=ACH-001650).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Ser834Ter (c.2501C>G); ClinVar=VCV000428733; Zygosity=Homozygous (Cosmic-CLP=1240212; DepMap=ACH-001650).
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.91
Native American0.11
East Asian, North79.2
East Asian, South9.59
South Asian0
European, North0
European, South7.19
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1240212; DepMap=ACH-001650; DSMZ=ACC-327; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D2S133819
D3S135815
D5S8189,12
D7S82011,12
D8S117912
D13S31711
D16S5399
D18S5114,16
D19S43314 (DSMZ=ACC-327)
14,16.2 (PubMed=25877200)
D21S1130,31
FGA23
Penta D11,13
Penta E11,13
TH017 (PubMed=25877200)
7,9 (Cosmic-CLP=1240212; DepMap=ACH-001650; DSMZ=ACC-327)
TPOX11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=21556646; DOI=10.3892/ijo.6.5.1099
Kenzo Sonoda, Manabu Nakashima, Toshiaki Saito, Satoshi Amada, Toshiharu Kamura, Hitoo Nakano, Takeshi Watanabe;
Establishment of a new human uterine cervical adenocarcinoma cell-line, SiSo, and its reactivity to anticancer reagents.
Int. J. Oncol. 6:1099-1104(1995)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35692560; DOI=10.1080/23723556.2022.2078628; PMCID=PMC9176225
Ma de Lourdes Zuniga-Martinez, Carlos Miguel Lopez-Mendoza, Jared Tenorio-Salazar, Alejandro Manuel Garcia-Carranca, Marco Antonio Cerbon-Cervantes, Luz Eugenia Alcantara-Quintana;
Establishment, authenticity, and characterization of cervical cancer cell lines.
Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-327
Cell line databases/resources CLO; CLO_0009021
cancercelllines; CVCL_2193
Cell_Model_Passport; SIDM00394
Cosmic-CLP; 1240212
DepMap; ACH-001650
DSMZCellDive; ACC-327
LINCS_LDP; LCL-1514
Biological sample resources BioSample; SAMN03470956
BioSample; SAMN03473350
Chemistry resources ChEMBL-Cells; CHEMBL3307272
ChEMBL-Targets; CHEMBL613527
GDSC; 1240212
PharmacoDB; SISO_1379_2019
PubChem_Cell_line; CVCL_2193
Encyclopedic resources Wikidata; Q54953520
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670424
Polymorphism and mutation databases Cosmic; 1995628
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number35