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Cellosaurus SHI-1 (CVCL_2191)

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Cell line name SHI-1
Synonyms shi-1; SHI1
Accession CVCL_2191
Resource Identification Initiative To cite this cell line use: SHI-1 (RRID:CVCL_2191)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Chinese.
Doubling time: ~36 hours (PubMed=15951289); ~60-70 hours (DSMZ=ACC-645).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:7137; AFDN + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFDN, MLL-MLLT4, MLL-AF6 (PubMed=15921626; PubMed=15951289).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000177881; Zygosity=Unspecified (DepMap=ACH-001647).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile195Thr (c.584T>C); ClinVar=VCV000216077; Zygosity=Unspecified (DepMap=ACH-001647).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute myeloid leukemia with t(6;11)(q27;q23) KMT2A-MLLT4 (NCIt: C132105)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001647; DSMZ=ACC-645

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133820,25
D3S135816,17
D5S81812,13
D7S82011,12
D8S117913,14
D13S3179
D16S5399,10
D18S5113
D19S43315,17
D21S1130,30.2
FGA21,24
Penta D9,10
Penta E11,14
TH016,7
TPOX8,9
vWA17

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Publications

PubMed=15921626; DOI=10.3760/cma.j.issn.0253-2727.2005.02.010
Su-Ning Chen, Yong-Quan Xue, Xue-Guang Zhang, Ya-Fang Wu, Jin-Lan Pan, Yong Wang, Jian-Nong Cen;
Establishment and characterization of a human acute monocytic leukemic cell line, SHI-1, carrying t(6;11)(q27;23) and p53 gene alteration.
Zhonghua Xue Ye Xue Za Zhi 26:94-99(2005)

PubMed=15951289
Su-Ning Chen, Yong-Quan Xue, Xue-Guang Zhang, Ya-Fang Wu, Jin-Lan Pan, Yong Wang, Jian-Nong Ceng;
A new human acute monocytic leukemia cell line SHI-1 with t(6;11)(q27;q23), p53 gene alterations and high tumorigenicity in nude mice.
Haematologica 90:766-775(2005)

Cross-references
Cell line collections (Providers) DSMZ; ACC-645
Cell line databases/resources cancercelllines; CVCL_2191
Cell_Model_Passport; SIDM01787
DepMap; ACH-001647
DSMZCellDive; ACC-645
Anatomy/cell type resources BTO; BTO_0005745
Biological sample resources BioSample; SAMN03473459
Encyclopedic resources Wikidata; Q54953339
Gene expression databases GEO; GSM1446762
Polymorphism and mutation databases Cosmic; 1601065
Cosmic; 1604864
IARC_TP53; 21615
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29