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Cellosaurus RS-5 (CVCL_2182)

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Cell line name RS-5
Synonyms RS5
Accession CVCL_2182
Resource Identification Initiative To cite this cell line use: RS-5 (RRID:CVCL_2182)
Comments Problematic cell line: May be misclassified. While still annotated as a pleural sarcomatoid mesothelioma cell line, a variety of omics methods are classifying this cell line as a fibroblast (DOI=10.1101/166199; DepMap=ACH-000531).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: ~4 days (DSMZ=ACC-604).
Omics: Transcriptomics; RNAseq.
Caution: Not directly described in the original publication, but indirectly mentioned ('Three others cell lines progressed in tissue culture') (PubMed=15372243).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,11:01
HLA-BB*35:01,44:02
HLA-CC*04:01,07:04
Class II
HLA-DQDQA1*01:02,05:02
DQB1*05:01,05:01
HLA-DRDRB1*11:02,14:46
Disease Pleural sarcomatoid mesothelioma (NCIt: C45663)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 78Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-604

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133819,22
D3S135814,15
D5S81812,13
D7S8209,11
D8S117912,13
D13S31711,12
D16S53911,12
D18S5113,17
D19S43313,14
D21S1130,32.2
FGA21
Penta D12
Penta E5,16
TH017,10
TPOX9,10
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=15372243; DOI=10.1007/s00418-004-0701-1
Marie-Marthe Philippeaux, Jean-Claude Pache, Sophie Dahoun, Marc Barnet, John-Henri Robert, Jacques Mauel, Anastase Spiliopoulos;
Establishment of permanent cell lines purified from human mesothelioma: morphological aspects, new marker expression and karyotypic analysis.
Histochem. Cell Biol. 122:249-260(2004)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

DOI=10.1101/166199
Antoine de Weck, Hans Bitter, Audrey Kauffmann;
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-604
Cell line databases/resources cancercelllines; CVCL_2182
Cell_Model_Passport; SIDM01772
DepMap; ACH-000531
DSMZCellDive; ACC-604
Biological sample resources BioSample; SAMN03473499
BioSample; SAMN10988436
Chemistry resources PharmacoDB; RS5_1330_2019
Encyclopedic resources Wikidata; Q54951295
Gene expression databases ArrayExpress; E-MTAB-2770
Polymorphism and mutation databases IARC_TP53; 30153
LiGeA; CCLE_175
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26