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Cellosaurus OCI-M2 (CVCL_2150)

[Text version]
Cell line name OCI-M2
Synonyms OCI M2; OCIM2
Accession CVCL_2150
Resource Identification Initiative To cite this cell line use: OCI-M2 (RRID:CVCL_2150)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
From: Ontario Cancer Institute (OCI); Toronto; Canada.
Doubling time: ~36 hours (DSMZ=ACC-619).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Sequence variations
  • Gene fusion; HGNC; HGNC:10471; RUNX1 + HGNC; HGNC:1268; TSPEAR; Name(s)=RUNX1-TSPEAR (PubMed=31160637).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (DepMap=ACH-001618).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Asp (c.821T>A); ClinVar=VCV000376675; Zygosity=Unspecified (DepMap=ACH-001618).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*08:01,44:02
HLA-CC*05:01,07:06

Source: DSMZCellDive=ACC-619
Class I
HLA-AA*02:01:01,02:01:01
HLA-BB*08:01:01,44:02:01
HLA-CC*05:01:01,07:01:01
Disease Acute erythroid leukemia (NCIt: C8923)
Acute erythroid leukemia (ORDO: Orphanet_318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001618; DSMZ=ACC-619; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D2S133818,24
D3S135815
D5S81811,12
D7S8208,11
D8S117910,13
D13S31711,14
D16S53911
D18S5116,20
D19S43314
D21S1129
FGA21
Penta D9 (DSMZ=ACC-619; PubMed=25877200)
9,12 (DepMap=ACH-001618)
Penta E10,12
TH018,9
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=3166384; DOI=10.1182/blood.V72.3.1029.1029
Thalia Papayannopoulou, Betty Nakamoto, Sumiko Kurachi, Mary Elizabeth Tweeddale, Hans August Messner;
Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations.
Blood 72:1029-1038(1988)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023)

Cross-references
Cell line collections (Providers) DSMZ; ACC-619
Cell line databases/resources cancercelllines; CVCL_2150
Cell_Model_Passport; SIDM01841
DepMap; ACH-001618
DSMZCellDive; ACC-619
Anatomy/cell type resources BTO; BTO_0004623
Biological sample resources BioSample; SAMN03473109
Chemistry resources PharmacoDB; OCIM2_1191_2019
Encyclopedic resources Wikidata; Q54931783
Experimental variables resources EFO; EFO_0006713
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM1374792
GEO; GSM1446760
Polymorphism and mutation databases Cosmic; 787472
Cosmic; 924044
Cosmic; 975294
Cosmic; 1012112
Cosmic; 1245830
Cosmic; 1281349
Cosmic; 1465962
Cosmic; 2306236
Cosmic; 2750870
IARC_TP53; 347
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number31