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Cellosaurus NMB (CVCL_2143)

[Text version]
Cell line name NMB
Accession CVCL_2143
Resource Identification Initiative To cite this cell line use: NMB (RRID:CVCL_2143)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: ~40-50 hours (DSMZ=ACC-657).
Karyotypic information: Hypotetraploid (PubMed=71759).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8901 (NMB-7)
Sex of cell Female
Age at sampling 10M
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001367; DSMZ=ACC-657

Markers:
AmelogeninX
CSF1PO11,12
D2S133820,23
D3S135815,17
D5S81811
D7S82010
D8S117914
D13S31711,12
D16S5399,13
D18S5117
D19S43311,13
D21S1128,29
FGA22,25
Penta D5,11
Penta E13,16
TH017,8
TPOX7,9
vWA17,18,20

Run an STR similarity search on this cell line
Publications

PubMed=71759; DOI=10.1126/science.71759
Gloria Brady Balaban-Malenbaum, Fred Gilbert;
Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line.
Science 198:739-741(1977)

PubMed=922665; DOI=10.1002/1097-0142(197711)40:5<2256::AID-CNCR2820400536>3.0.CO;2-1
Garrett M. Brodeur, Gurbax Singh Sekhon, Milton N. Goldstein;
Chromosomal aberrations in human neuroblastomas.
Cancer 40:2256-2263(1977)

DOI=10.1016/B978-0-12-008304-6.50015-4
June Lee Biedler, Marian B. Meyers, Barbara A. Spengler;
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff, Sergey & Hertz, Leif (eds.); pp.267-307; Academic Press; New York; USA (1983)

PubMed=6888561; DOI=10.1038/305245a0
Manfred Schwab, Kari Alitalo, Karl-Heinz Klempnauer, Harold Eliot Varmus, John Michael Bishop, Fred Gilbert, Garrett M. Brodeur, Milton N. Goldstein, Jeffrey M. Trent;
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Nature 305:245-248(1983)

PubMed=3000378; DOI=10.1016/0006-291X(85)91841-8
March D. Ard, Milton N. Goldstein, David R. Nash, David I. Gottlieb;
NMB: a human neuroblastoma cell line with specific opiate binding sites.
Biochem. Biophys. Res. Commun. 133:60-66(1985)

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

PubMed=11550280; DOI=10.1002/gcc.1174
Nadine Van Roy, Heidi Van Limbergen, Jo Vandesompele, Mireille Van Gele, Bruce Poppe, Helen R. Salwen, Genevieve Laureys, Nunes Manoel, Anne De Paepe, Frank Speleman;
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Genes Chromosomes Cancer 32:126-135(2001)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys ...Show all 22 authors... , Frank Speleman, Cecilia Kim, Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027
Michael Holzel, Si-Dong Huang, Jan Koster, Ingrid Ora, Arjan Lakeman, Huib Nicolaas Caron, Wouter Nijkamp, Jing Xie, Tom Callens, Shahab Asgharzadeh, Robert C. Seeger ...Show all 14 authors... , Ludwine M. Messiaen, Rogier Versteeg, Rene Bernards; Show fewer authors
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Joanna E. Gawecka, Dirk Geerts, Jan Koster, Maisel J. Caliva, Florian J. Sulzmaier, John Opoku-Ansah, Randal K. Wada, Andre S. Bachmann, Joe W. Ramos;
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

Cross-references
Cell line collections (Providers) DSMZ; ACC-657
Cell line databases/resources cancercelllines; CVCL_2143
Cell_Model_Passport; SIDM01383
DepMap; ACH-001367
DSMZCellDive; ACC-657
Anatomy/cell type resources BTO; BTO_0005872
Biological sample resources BioSample; SAMN03473470
Encyclopedic resources Wikidata; Q54930830
Gene expression databases GEO; GSM692862
GEO; GSM2371251
GEO; GSM2394366
Polymorphism and mutation databases Cosmic; 717422
Cosmic; 848937
Cosmic; 930073
Cosmic; 1019940
Cosmic; 1109119
Cosmic; 1109368
Cosmic; 1162001
Cosmic; 1167991
Cosmic; 1518072
Cosmic; 1526639
Cosmic; 1543774
Cosmic; 2239465
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30