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Cellosaurus NCI-H69/LX10 (CVCL_2138)

[Text version]
Cell line name NCI-H69/LX10
Synonyms H69/LX10
Accession CVCL_2138
Resource Identification Initiative To cite this cell line use: NCI-H69/LX10 (RRID:CVCL_2138)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=27247353; DOI=10.1093/jnci/djw122; PMCID=PMC6279282
Polley E.C., Kunkel M.W., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Fer N., Sonkin D., Kaur G., Monks A., Malik S., Morris J., Teicher B.A.
Small cell lung cancer screen of oncology drugs, investigational agents, and gene and microRNA expression.
J. Natl. Cancer Inst. 108:djw122.1-djw122.11(2016)

PubMed=28766886; DOI=10.1002/cam4.1131; PMCID=PMC5548882
Teicher B.A., Silvers T.E., Selby M., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Parchment R.E., Krushkal J., Sonkin D., Rubinstein L., Morris J., Evans D.
Small cell lung carcinoma cell line screen of etoposide/carboplatin plus a third agent.
Cancer Med. 6:1952-1964(2017)

Cross-references
Cell line collections (Providers) ECACC; 96042331
Cell line databases/resources cancercelllines; CVCL_2138
Encyclopedic resources Wikidata; Q54908105
Gene expression databases GEO; GSM1887949
GEO; GSM1888025
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22