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Cellosaurus MOTN-1 (CVCL_2127)

[Text version]
Cell line name MOTN-1
Synonyms MOTN1
Accession CVCL_2127
Resource Identification Initiative To cite this cell line use: MOTN-1 (RRID:CVCL_2127)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Population: Japanese.
Characteristics: IL2 dependent.
Doubling time: 24 hours (PubMed=12127564); ~30-40 hours (DSMZ=ACC-559).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
HLA typing Source: DSMZCellDive=ACC-559
Class I
HLA-AA*02:01:01,02:06:01
HLA-BB*54:01:01,56:01:01
HLA-CC*01:02:01,01:02:01
Class II
HLA-DPDPA1*02:02:02,02:02:02
DPB1*05:01:01,05:01:01
HLA-DQDQA1*03:01:01,03:03:01
DQB1*03:02:01,04:01:01
HLA-DRDRA*01:01:01,01:02:02
DRB1*04:05:01,08:02:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.84
Native American0.4
East Asian, North73.72
East Asian, South24.39
South Asian0
European, North0
European, South0.64
Disease T-cell large granular lymphocyte leukemia (NCIt: C4664)
T-cell large granular lymphocyte leukemia (ORDO: Orphanet_86872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L208 ! PLT-2
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-559; JCRB=JCRB1847

Markers:
AmelogeninX
CSF1PO12,13
D2S133819
D3S135816,17
D5S81810
D7S82010,12
D8S117915
D13S31711,12 (JCRB=JCRB1847)
12 (DSMZ=ACC-559)
D16S5399,11
D18S5116
D19S43313,14
D21S1130,31
FGA21,24
Penta D9
Penta E16,18
TH016
TPOX11
vWA14,19

Run an STR similarity search on this cell line
Publications

PubMed=12127564; DOI=10.1016/S0145-2126(02)00023-1
Yoshinobu Matsuo, Hans Gunther Drexler, Makoto Takeuchi, Masanobu Tanaka, Kunzo Orita;
Establishment of the T-cell large granular lymphocyte leukemia cell line MOTN-1 carrying natural killer-cell antigens.
Leuk. Res. 26:873-879(2002)

PubMed=14712486; DOI=10.1002/ijc.11647
Masanori Daibata, Yoshinobu Matsuo, Haruhiko Machida, Takahiro Taguchi, Yuji Ohtsuki, Hirokuni Taguchi;
Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56+ T-cell large granular lymphocyte leukemia.
Int. J. Cancer 108:845-851(2004)

PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x; PMCID=PMC11159954
Angen Liu, Tetsuya Takakuwa, Wen-Juan Luo, Shigeki Fujita, Katsuyuki Aozasa;
Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection.
Cancer Sci. 97:605-610(2006)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-559
JCRB; JCRB1847
Cell line databases/resources cancercelllines; CVCL_2127
Cell_Model_Passport; SIDM01884
DepMap; ACH-001130
DSMZCellDive; ACC-559
Biological sample resources BioSample; SAMN03473538
BioSample; SAMN10988469
Chemistry resources PharmacoDB; MOTN1_963_2019
Encyclopedic resources Wikidata; Q54906412
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM887340
GEO; GSM888416
Polymorphism and mutation databases IARC_TP53; 28296
Progenetix; CVCL_2127
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30