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Cellosaurus MOLT-17 (CVCL_2125)

[Text version]
Cell line name MOLT-17
Synonyms Molt-17; MOLT 17; MOLT17
Accession CVCL_2125
Resource Identification Initiative To cite this cell line use: MOLT-17 (RRID:CVCL_2125)
Comments Problematic cell line: Partially contaminated. The RCB/Riken RCB1982 stock was contaminated and was replaced by RCB4561 which originates from DSMZ ACC-36. On the basis of STR profile, the version at TKG (TKG 0385) seems to be identical or closely related to the RCB1962 contaminated stock.
Population: African American.
Doubling time: ~50 hours (DSMZ=ACC-36).
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1424 ! MOLT-16
Sex of cell Female
Age at sampling 5Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-36; RCB=RCB1982; TKG=TKG 0385

Markers:
AmelogeninX
CSF1PO9,10,12 (RCB=RCB1982)
10,12 (TKG=TKG 0385)
11,12 (DSMZ=ACC-36)
D2S133819,21
D3S135814,17
D5S81811,12 (DSMZ=ACC-36)
12 (TKG=TKG 0385)
12,13 (RCB=RCB1982)
D7S82011 (TKG=TKG 0385)
11,12,13 (RCB=RCB1982)
12 (DSMZ=ACC-36)
D8S117914
D13S31710,11,12 (RCB=RCB1982)
10,12 (TKG=TKG 0385)
12 (DSMZ=ACC-36)
D16S5399,10 (DSMZ=ACC-36)
9,14,15 (RCB=RCB1982)
9,15 (TKG=TKG 0385)
D18S5114,15,20
D19S43310,13
D21S1132.2,33.2
FGA23,24
Penta D6,10
Penta E16
TH019 (RCB=RCB1982; TKG=TKG 0385)
9,9.3 (DSMZ=ACC-36)
TPOX8 (RCB=RCB1982; TKG=TKG 0385)
8,11 (DSMZ=ACC-36)
vWA16 (DSMZ=ACC-36)
17,18,19 (RCB=RCB1982)
18,19 (TKG=TKG 0385)

Run an STR similarity search on this cell line
Web pages Info; RCB; -; https://cell.brc.riken.jp/en/announcement/molt-17
Publications

PubMed=2961573; DOI=10.1002/eji.1830171208
Lynette Tighe, Alan Forster, David M. Clark, Arthur W. Boylston, Isabella Lavenir, Terence Howard Rabbitts;
Unusual forms of T cell gamma mRNA in a human T cell leukemia cell line: implications for gamma gene expression.
Eur. J. Immunol. 17:1729-1736(1987)

PubMed=2784121; DOI=10.1002/hon.2900070203
Hans Gunther Drexler, Jun Minowada;
Morphological, immunophenotypical and isoenzymatic profiles of human leukemia cells and derived T-cell lines.
Hematol. Oncol. 7:115-125(1989)

PubMed=8127147
Mats Heyman, Dan Grander, Karen Brondum-Nielsen, Britta Cederblad, Yie Liu, Bo Xu, Stefan Einhorn;
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x
Laura Borgonovo-Brandter, Mats Heyman, Omid Rasool, Y. Liu, Dan Grander, Stefan Einhorn;
p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.
Eur. J. Haematol. 56:313-318(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Paivi Ostling ...Show all 17 authors... , Olli-Pekka Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtio, Mattias Vesterlund, Rozbeh Jafari; Show fewer authors
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-36
NCBI_Iran; C516
RCB; RCB1982 - Discontinued
RCB; RCB4561
TKG; TKG 0385 - Discontinued
Cell line databases/resources CLO; CLO_0051012
CLDB; cl3517
Cell_Model_Passport; SIDM00430
DSMZCellDive; ACC-36
Anatomy/cell type resources BTO; BTO_0004174
Biological sample resources BioSample; SAMN03472051
Encyclopedic resources Wikidata; Q54906348
Gene expression databases GEO; GSM5137762
Polymorphism and mutation databases Cosmic; 933539
Cosmic; 1118461
Cosmic; 2602928
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number28