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Cellosaurus L-1236 (CVCL_2096)

[Text version]
Cell line name L-1236
Synonyms L1236; L 1236
Accession CVCL_2096
Secondary accession CVCL_5155
Resource Identification Initiative To cite this cell line use: L-1236 (RRID:CVCL_2096)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: ~48 hours (DSMZ=ACC-530).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq virome analysis.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11896; TNFAIP3; Zygosity=Heterozygous (PubMed=19380639).
  • Mutation; HGNC; HGNC:11896; TNFAIP3; Simple; p.Trp142Ter (c.425G>A) (G491A); Zygosity=Heterozygous (PubMed=19380639).
  • Mutation; HGNC; HGNC:11998; TP53; Unexplicit; Fusion of Ex9 wiith an Alu-element; Zygosity=Unspecified (PubMed=17065008).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*51:01,51:01
HLA-CC*02:02,02:02

Source: DSMZCellDive=ACC-530
Class I
HLA-AA*02:01:01,02:01:01
HLA-BB*51:01:01,51:01:01
HLA-CC*02:02:02,02:02:02
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:01:01,04:01:01
HLA-DQDQA1*01:02:01,01:04:01
DQB1*05:03:01,05:03:01
HLA-DRDRA*01:01:01,01:01:01
DRB1*14:54:01,14:54:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North1.96
East Asian, South0
South Asian0.15
European, North70.78
European, South27.1
Disease Hodgkin lymphoma (NCIt: C9357)
Hodgkin lymphoma (ORDO: Orphanet_98293)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 34Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1330935; DSMZ=ACC-530

Markers:
AmelogeninX,Y
CSF1PO10,14
D2S133818
D3S135815,16
D5S81811,13
D7S8209,10
D8S117912,13
D13S31713
D16S5399,13
D18S5115,19
D19S43314,17
D21S1127
FGA21,25
Penta D10
Penta E7,10
TH016
TPOX8,12
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=8605360; DOI=10.1182/blood.V87.8.3418.bloodjournal8783418
Jurgen Wolf, Ursula Kapp, Heribert Bohlen, Martin Kornacker, Claudia Schoch, Bettina Stahl, Susanne Mucke, Christof von Kalle, Christa Fonatsch, Hans-Eckart Schaefer, Martin-Leo Hansmann, Volker Diehl;
Peripheral blood mononuclear cells of a patient with advanced Hodgkin's lymphoma give rise to permanently growing Hodgkin-Reed Sternberg cells.
Blood 87:3418-3428(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12865944; PMCID=PMC1430727
Ines Schwering, Andreas Brauninger, Verena Distler, Julia Jesdinsky, Volker Diehl, Martin-Leo Hansmann, Klaus Rajewsky, Ralf Kuppers;
Profiling of Hodgkin's lymphoma cell line L1236 and germinal center B cells: identification of Hodgkin's lymphoma-specific genes.
Mol. Med. 9:85-95(2003)

PubMed=17065008; DOI=10.1080/10428190600667721
Alexander Feuerborn, Constanze Moritz, Frederike von Bonin, Matthias Dobbelstein, Lorenz Trumper, Benjamin Sturzenhofecker, Dieter Kube;
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.
Leuk. Lymphoma 47:1932-1940(2006)

PubMed=19380639; DOI=10.1084/jem.20090528; PMCID=PMC2715030
Roland Schmitz, Martin-Leo Hansmann, Verena Bohle, Jose Ignacio Martin-Subero, Sylvia Hartmann, Gunhild Mechtersheimer, Wolfram Klapper, Inga Vater, Maciej Giefing, Stefan Gesk, Jens Stanelle ...Show all 13 authors... , Reiner Siebert, Ralf Kuppers; Show fewer authors
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
J. Exp. Med. 206:981-989(2009)

PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356
Michael Richard Green, Stefano Monti, Scott J. Rodig, Przemyslaw Juszczynski, Treeve Currie, Evan O'Donnell, Bjoern Chapuy, Kunihiko Takeyama, Donna Neuberg, Todd Robert Golub, Jeffery L. Kutok, Margaret Ann Shipp;
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14; PMCID=PMC4301145
Su-Bing Cao, Michael J. Strong, Xia Wang, Walter N. Moss, Monica Concha, Zhen Lin, Tina O'Grady, Melody Baddoo, Claire Fewell, Rolf Renne, Erik K. Flemington;
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Hans Gunther Drexler, Claudia Pommerenke, Sonja Eberth, Stefan Nagel;
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-530
Cell line databases/resources CLO; CLO_0037179
cancercelllines; CVCL_2096
Cell_Model_Passport; SIDM00313
Cosmic-CLP; 1330935
DepMap; ACH-000702
DSMZCellDive; ACC-530
IGRhCellID; L1236
LINCS_LDP; LCL-2010
Lonza; 25
Biological sample resources BioSample; SAMN03473524
BioSample; SAMN10987806
Chemistry resources GDSC; 1330935
PharmacoDB; L1236_813_2019
Encyclopedic resources Wikidata; Q54900859
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM381297
GEO; GSM499722
GEO; GSM499730
GEO; GSM552449
GEO; GSM646531
GEO; GSM646536
GEO; GSM887257
GEO; GSM888332
GEO; GSM1670027
Polymorphism and mutation databases Cosmic; 988702
Cosmic; 1013908
Cosmic; 1289701
Cosmic; 1432037
Cosmic; 2276328
Cosmic; 2464306
IARC_TP53; 23617
LiGeA; CCLE_723
Progenetix; CVCL_2096
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39