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Cellosaurus Kelly (CVCL_2092)

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Cell line name Kelly
Synonyms KELLY; NB19; NB-19; NB19-RIKEN
Accession CVCL_2092
Secondary accession CVCL_B322
Resource Identification Initiative To cite this cell line use: Kelly (RRID:CVCL_2092)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Characteristics: MYCN-amplified NBL cell line.
Virology: Infected with a murine leukemia virus-related virus (PubMed=30629668).
Doubling time: ~30 hours (CLS=300317); ~30-40 hours (DSMZ=ACC-355).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K4me1.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; Chromatin accessibility; ATAC-seq.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; RNAseq; Single cell.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (PubMed=18724359; PubMed=28350380; Cosmic-CLP=753618; DepMap=ACH-000259).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro177Thr (c.529C>A); ClinVar=VCV000482220; Zygosity=Homozygous (Cosmic-CLP=753618; DepMap=ACH-000259).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,01:01
HLA-BB*08:01,51:01
HLA-CC*03:03,07:01
Class II
HLA-DQDQA1*03:02,03:02
HLA-DRDRB1*07:01,12:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.15
Native American0
East Asian, North2.95
East Asian, South0
South Asian0
European, North61.68
European, South33.22
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753618; DSMZ=ACC-355; ECACC=92110411; PubMed=25877200; RCB=RCB0479; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO12
D1S165611,13
D2S44110,14
D2S133817,20
D3S135814,16
D5S81811,13
D7S8209
D8S117914
D10S124813,14
D12S39119,20
D13S31710,14 (ECACC=92110411; RCB=RCB0479; Technion Genomics Center)
14 (Cosmic-CLP=753618; DSMZ=ACC-355; PubMed=25877200)
D16S53912,13
D18S5114,17
D19S43312,15.2 (Technion Genomics Center)
12,16 (DSMZ=ACC-355)
D21S1128,30
D22S104516
FGA20,21
Penta D9,14
Penta E12,16
TH019.3
TPOX8,10
vWA16,18 (ECACC=92110411; RCB=RCB0479; Technion Genomics Center)
18 (Cosmic-CLP=753618; DSMZ=ACC-355; PubMed=25877200)

Run an STR similarity search on this cell line
Publications

PubMed=7139592; DOI=10.1016/0165-4608(82)90105-4
Fred Gilbert, Gloria Brady Balaban-Malenbaum, Paul Sidney Moorhead, Diana W. Bianchi, Harvey R. Schlesinger;
Abnormalities of chromosome 1p in human neuroblastoma tumors and cell lines.
Cancer Genet. Cytogenet. 7:33-42(1982)

PubMed=6888561; DOI=10.1038/305245a0
Manfred Schwab, Kari Alitalo, Karl-Heinz Klempnauer, Harold Eliot Varmus, John Michael Bishop, Fred Gilbert, Garrett M. Brodeur, Milton N. Goldstein, Jeffrey M. Trent;
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Nature 305:245-248(1983)

PubMed=2846152
Peter N. Preis, Hideyuki Saya, Laszlo Nadasdi, Guenther Hochhaus, Victor Alan Levin, Wolfgang Sadee;
Neuronal cell differentiation of human neuroblastoma cells by retinoic acid plus herbimycin A.
Cancer Res. 48:6530-6534(1988)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=10630978; DOI=10.1667/0033-7587(2000)153[0062:FORIMI]2.0.CO;2
John M. Akudugu, Jacobus Petrus Slabbert, Antonio Mendes Serafin, Lothar Bohm;
Frequency of radiation-induced micronuclei in neuronal cells does not correlate with clonogenic survival.
Radiat. Res. 153:62-67(2000)

PubMed=11668190; DOI=10.1177/002215540104901105
Hilmar Quentmeier, Mary Osborn, Julia Reinhardt, Margarete Zaborski, Hans Gunther Drexler;
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=17506115; DOI=10.1002/nbm.1181
Andrew C. Peet, Carmel M. McConville, Martin Paul Wilson, Barry A. Levine, Michelle Reed, Sara A. Dyer, Emma C. Edwards, Mary C. Strachan, Dominic J. McMullan, Timothy M. Wilkes, Richard G. Grundy;
1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.
NMR Biomed. 20:692-700(2007)

PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026
Hiroaki Komuro, Ryoko Saihara, Miki Shinya, Junko Takita, Setsuko Kaneko, Michio Kaneko, Yasuhide Hayashi;
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
J. Pediatr. Surg. 42:2040-2045(2007)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys ...Show all 22 authors... , Frank Speleman, Cecilia Kim, Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=18923524; DOI=10.1038/nature07399
Yu-Yan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Li-Li Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara ...Show all 14 authors... , Yasuhide Hayashi, Hiroyuki Mano, Seishi Ogawa; Show fewer authors
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=33525507; DOI=10.3390/biom11020177; PMCID=PMC7912277
Daniele Mercatelli, Nicola Balboni, Alessandro Palma, Emanuela Aleo, Pietro Paolo Sanna, Giovanni Perini, Federico Manuel Giorgi;
Single-cell gene network analysis and transcriptional landscape of MYCN-amplified neuroblastoma cell lines.
Biomolecules 11:177.1-177.18(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=39255063; DOI=10.1016/j.celrep.2024.114711
Maja-Celine Stober, Rocio Chamorro Gonzalez, Lotte Bruckner, Thomas Conrad, Nadine Wittstruck, Annabell Krienelke Szymansky, Angelika Eggert, Johannes Hubertus Schulte, Richard Patrick Koche, Anton George Henssen, Roland F. Schwarz, Kerstin Haase;
Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity.
Cell Rep. 43:114711.1-114711.19(2024)

Cross-references
Cell line collections (Providers) CLS; 300317
DSMZ; ACC-355
ECACC; 92110411
RCB; RCB0479 - Discontinued
Cell line databases/resources CLO; CLO_0007091
CLO; CLO_0051540
CLDB; cl3020
cancercelllines; CVCL_2092
Cell_Model_Passport; SIDM01009
Cosmic-CLP; 753618
DepMap; ACH-000259
DSMZCellDive; ACC-355
LINCS_LDP; LCL-1966
Lonza; 1024
Anatomy/cell type resources BTO; BTO_0006213
Biological sample resources BioSample; SAMN03472324
BioSample; SAMN03473084
BioSample; SAMN03473316
BioSample; SAMN10988299
CRISP screens repositories BioGRID_ORCS_Cell_line; 623
Chemistry resources ChEMBL-Cells; CHEMBL4651376
GDSC; 753618
PharmacoDB; KELLY_743_2019
PubChem_Cell_line; CVCL_2092
Encyclopedic resources Wikidata; Q54899802
Experimental variables resources EFO; EFO_0002069
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM313805
GEO; GSM313806
GEO; GSM333801
GEO; GSM563354
GEO; GSM887206
GEO; GSM888279
GEO; GSM1366407
GEO; GSM1669983
GEO; GSM2371238
GEO; GSM2394386
GEO; GSM3145616
GEO; GSM3145714
GEO; GSM4104577
GEO; GSM4104578
GEO; GSM4104626
GEO; GSM4104627
GEO; GSM4105308
GEO; GSM4105309
GEO; GSM4105310
GEO; GSM4105311
GEO; GSM4105312
Polymorphism and mutation databases Cosmic; 688077
Cosmic; 753618
Cosmic; 801738
Cosmic; 920246
Cosmic; 947704
Cosmic; 1037341
Cosmic; 1099138
Cosmic; 1109365
Cosmic; 1153786
Cosmic; 1161990
Cosmic; 1167409
Cosmic; 1167987
Cosmic; 1212537
Cosmic; 1995468
Cosmic; 2058107
Cosmic; 2131576
Cosmic; 2393634
Cosmic; 2485945
IARC_TP53; 28354
LiGeA; CCLE_776
Progenetix; CVCL_2092
Progenetix; CVCL_B322
Proteomic databases PRIDE; PXD003596
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number44