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Cellosaurus KB-V1 (CVCL_2089)

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Cell line name KB-V1
Synonyms KB-v1; KB-V-1; KBV1
Accession CVCL_2089
Resource Identification Initiative To cite this cell line use: KB-V1 (RRID:CVCL_2089)
Comments Problematic cell line: Contaminated. Grand-parent cell line (KB) has been shown to be a HeLa derivative.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00373.
Population: African American.
Doubling time: ~50 hours (DSMZ=ACC-149).
Selected for resistance to: ChEBI; CHEBI_27375; Vincaleukoblastine (Vinblastine).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2088 (KB-3-1)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-149; PubMed=22118813

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135815,17,18
D5S81811,12
D7S8208,12
D8S117912,13
D13S31712,13.3 (DSMZ=ACC-149)
12,14 (PubMed=22118813)
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28
FGA21
Penta D8,15
Penta E7,17
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Provider; NIH OTT; E-007-2006/0-6; https://web.archive.org/web/20150922130003/http://www.ott.nih.gov/erma/multidrug-resistant-epidermal-carcinoma-cell-line-kb-v-1
Publications

PubMed=3711108; DOI=10.1016/S0021-9258(19)57466-X
Ding-Wu Shen, Carol O. Cardarelli, Jaulang Hwang, Marilyn Cornwell, Nancy Richert, Shunsuke Ishii, Ira Pastan, Michael Marc Gottesman;
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
J. Biol. Chem. 261:7762-7770(1986)

PubMed=2897240; DOI=10.1016/0092-8674(88)90568-5
Kyunghee Choi, Chang-Jie Chen, Michael Kriegler, Igor B. Roninson;
An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.
Cell 53:519-529(1988)

PubMed=7865904
Xiao-Ping Zhang, Mary K. Ritke, Jack Charles Yalowich, Marilyn L. Slovak, Jennifer Pelkey Ho, Karen I. Collins, Tami Annable, Robert John Arceci, Frederick E. Durr, Lee M. Greenberger;
P-glycoprotein mediates profound resistance to bisantrene.
Oncol. Res. 6:291-301(1994)

PubMed=22118813; DOI=10.1016/j.canlet.2011.09.038
Till Krech, Elisa Scheuerer, Robert Geffers, Hans-Heinrich Kreipe, Ulrich Lehmann, Matthias Christgen;
ABCB1/MDR1 contributes to the anticancer drug-resistant phenotype of IPH-926 human lobular breast cancer cells.
Cancer Lett. 315:153-160(2012)

Cross-references
Cell line collections (Providers) DSMZ; ACC-149
Cell line databases/resources CLO; CLO_0007077
CLDB; cl3009
DSMZCellDive; ACC-149
Anatomy/cell type resources BTO; BTO_0003917
Biological sample resources BioSample; SAMN03151732
Chemistry resources ChEMBL-Cells; CHEMBL4295414
ChEMBL-Targets; CHEMBL4296451
PubChem_Cell_line; CVCL_2089
Encyclopedic resources Wikidata; Q54899567
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26