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Cellosaurus ESO-26 (CVCL_2035)

[Text version]
Cell line name ESO-26
Synonyms ESO26
Accession CVCL_2035
Resource Identification Initiative To cite this cell line use: ESO-26 (RRID:CVCL_2035)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: ~35-50 hours (DSMZ=ACC-708).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Esophagus, distal; UBERON=UBERON_0013473.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.22
Native American0
East Asian, North0
East Asian, South2.45
South Asian0.14
European, North50.67
European, South43.52
Disease Gastroesophageal junction adenocarcinoma (NCIt: C9296)
Carcinoma of esophagus (ORDO: Orphanet_70482)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1503366; DepMap=ACH-001496; DSMZ=ACC-708; ECACC=11012009; PubMed=20075370

Markers:
AmelogeninX,Y
CSF1PO9,10
D2S133819,23
D3S135815
D5S81812
D7S82011
D8S117913,14
D13S3179,11
D16S5399
D18S5117
D19S43314
D21S1130
FGA21
Penta D10
Penta E12,14
TH019
TPOX7,9
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=20075370; DOI=10.1093/jnci/djp499; PMCID=PMC2902814
Jurjen J. Boonstra, Ronald van Marion, David G. Beer, Lin Lin, Patricia Chaves, Catarina Ribeiro, A. Dias Pereira, Lucia Roque, S. Jane Darnton, Nasser Khaled Altorki, David S. Schrump ...Show all 19 authors... , David S. Klimstra, Laura H. Tang, James Richard Eshleman, Hector Alvarez, Yutaka Shimada, Herman van Dekken, Hugo W. Tilanus, Winand N.M. Dinjens; Show fewer authors
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Jurjen J. Boonstra, Hugo W. Tilanus, Winand N.M. Dinjens;
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

PubMed=27594985; DOI=10.12688/f1000research.7033.1; PMCID=PMC4991527
Gianmarco Contino, Matthew D. Eldridge, Maria Secrier, Lawrence Bower, Rachael Fels Elliott, Jamie Weaver, Andy G. Lynch, Paul A.W. Edwards, Rebecca Clare Fitzgerald;
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.
F1000Research 5:1336.1-1336.12(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-708
ECACC; 11012009
Cell line databases/resources cancercelllines; CVCL_2035
Cell_Model_Passport; SIDM00539
Cosmic-CLP; 1503366
DepMap; ACH-001496
DSMZCellDive; ACC-708
Biological sample resources BioSample; SAMN03473393
CRISP screens repositories BioGRID_ORCS_Cell_line; 889
Chemistry resources GDSC; 1503366
PharmacoDB; ESO26_345_2019
Encyclopedic resources Wikidata; Q54832832
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669776
Polymorphism and mutation databases Cosmic; 1599336
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number33