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Cellosaurus DM-3 (CVCL_2019)

[Text version]

Cell line name DM-3
Synonyms DM3
Accession CVCL_2019
Resource Identification Initiative To cite this cell line use: DM-3 (RRID:CVCL_2019)
Comments Problematic cell line: May be misclassified. While still annotated as a pleural sarcomatoid mesothelioma cell line, a variety of omics methods are classifying this cell line as a fibroblast (DOI=10.1101/166199; DepMap).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 54 hours (PubMed=23840376); ~50-60 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Sequence variations
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Arg496Leu (c.1487G>T); Zygosity=Homozygous (DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North0.58
East Asian, South0.68
South Asian2.16
European, North58.64
European, South37.94
Disease Pleural sarcomatoid mesothelioma (NCIt: C45663)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133817,18
D3S135815,16
D5S81812,13
D7S8208,10
D8S117911,15
D13S31711
D16S5399,13
D18S5112,15
D19S43313,14
D21S1129,30
FGA19,20
Penta D11,12
Penta E7,12
TH016
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=15372243; DOI=10.1007/s00418-004-0701-1
Philippeaux M.-M., Pache J.-C., Dahoun S., Barnet M., Robert J.-H., Mauel J., Spiliopoulos A.
Establishment of permanent cell lines purified from human mesothelioma: morphological aspects, new marker expression and karyotypic analysis.
Histochem. Cell Biol. 122:249-260(2004)

PubMed=23840376; DOI=10.1371/journal.pone.0065903
Szulkin A., Nilsonne G., Mundt F., Wasik A.M., Souri P., Hjerpe A., Dobra K.
Variation in drug sensitivity of malignant mesothelioma cell lines with substantial effects of selenite and bortezomib, highlights need for individualized therapy.
PLoS ONE 8:E65903-E65903(2013)

DOI=10.1101/166199
de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=33567673; DOI=10.3390/cancers13040685
Keller M., Reis K., Hjerpe A., Dobra K., Aspenstrom P.
Cytoskeletal organization correlates to motility and invasiveness of malignant mesothelioma cells.
Cancers (Basel) 13:685.1-685.20(2021)

Cross-references
Cell line collections DSMZ; ACC-595
Cell line databases/resources Cell_Model_Passport; SIDM01505
DepMap; ACH-000742
DSMZCellDive; ACC-595
Biological sample resources BioSample; SAMN03473059
BioSample; SAMN10988453
Chemistry resources PharmacoDB; DM3_295_2019
Encyclopedic resources Wikidata; Q54831188
Gene expression databases ArrayExpress; E-MTAB-2770
Polymorphism and mutation databases IARC_TP53; 30031
LiGeA; CCLE_782
Progenetix; CVCL_2019
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number23