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Cellosaurus DERL-7 (CVCL_2017)

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Cell line name DERL-7
Synonyms DERL7; DERL-NK7
Accession CVCL_2017
Resource Identification Initiative To cite this cell line use: DERL-7 (RRID:CVCL_2017)
Comments Part of: LL-100 blood cancer cell line panel.
Doubling time: 72 hours (PubMed=11587224); ~30 hours (DSMZ=ACC-524).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: T-cell; CL=CL_0000084.
HLA typing Source: DSMZCellDive=ACC-524
Class I
HLA-AA*02:01:01,26:01:01
HLA-BB*38:01:01,51:01:01
HLA-CC*02:02:02,12:03:01
Disease Hepatosplenic T-cell lymphoma (NCIt: C8459)
Hepatosplenic T-cell lymphoma (ORDO: Orphanet_86882)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2016 ! DERL-2
Sex of cell Male
Age at sampling 30Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-524; PubMed=11587224

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133823,24
D3S135814,15
D5S81810,11
D7S82011,12
D8S117913,14
D13S31711,12
D16S53910,11
D18S5114
D19S43313,15
D21S1129,30
FGA20,22 (DSMZ=ACC-524)
21,22 (PubMed=11587224)
Penta D11,13
Penta E11,14
TH019
TPOX8,11
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=10800166
Andrea Camera, Luca Pezzullo, Maria Rosaria Villa, Luigia Luciano, Fabrizio Pane, Barbara Izzo, Piernicola Boccuni, Rosa Di Noto, Luigi Del Vecchio, Francesco Salvatore, Bruno Rotoli;
Coexistence of two distinct cell populations (CD56(+)TcRgammadelta(+) and CD56(+)TcRgammadelta(-)) in a case of aggressive CD56(+) lymphoma/leukemia.
Haematologica 85:496-501(2000)

PubMed=11587224; DOI=10.1038/sj.leu.2402239
Rosa Di Noto, Fabrizio Pane, Andrea Camera, Luigia Luciano, Maria Vittoria Barone, Catia Lo Pardo, Piernicola Boccuni, Mariano Intrieri, Barbara Izzo, Maria Rosaria Villa, M. Macri ...Show all 15 authors... , Bruno Rotoli, Lucia Sacchetti, Francesco Salvatore, Luigi Del Vecchio; Show fewer authors
Characterization of two novel cell lines, DERL-2 (CD56+/CD3+/Tcry5+) and DERL-7 (CD56+/CD3-/TCRgammadelta-), derived from a single patient with CD56+ non-Hodgkin's lymphoma.
Leukemia 15:1641-1649(2001)

PubMed=28122867; DOI=10.1158/2159-8290.CD-16-0330; PMCID=PMC5402251
Matthew McKinney, Andrea B. Moffitt, Philippe Gaulard, Marion Travert, Laurence de Leval, Alina Nicolae, Mark Raffeld, Elaine Sarkin Jaffe, Stefania Pittaluga, Li-Qiang Xi, Tayla Heavican ...Show all 56 authors... , Javeed Iqbal, Karim Belhadj, Marie-Helene Delfau-Larue, Virginie Fataccioli, Magdalena B. Czader, Izidore S. Lossos, Jennifer Rose Chapman-Fredricks, Kristy L. Richards, Yuri Fedoriw, Sarah L. Ondrejka, Eric Darryl Hsi, Lawrence Low, Dennis D. Weisenburger, Wing-Chung Chan, Neha Mehta-Shah, Steven Horwitz, Leon Bernal-Mizrachi, Christopher Robert Flowers, Anne W. Beaven, Mayur Parihar, Lucile Baseggio, Marie Parrens, Anne Moreau, Pierre Sujobert, Monika Pilichowska, Andrew M. Evens, Amy Chadburn, Rex Kwok-Him Au-Yeung, Gopesh Srivastava, William Wai-Lap Choi, John R. Goodlad, Igor Aurer, Sandra Basic-Kinda, Randy D. Gascoyne, Nicholas S. Davis, Guo-Jie Li, Jenny Zhang, Deepthi Rajagopalan, Anupama Reddy, Cassandra L. Love, Shawn Levy, Yuan Zhuang, Jyotishka Datta, David Brian Dunson, Sandeep S. Dave; Show fewer authors
The genetic basis of hepatosplenic T-cell lymphoma.
Cancer Discov. 7:369-379(2017)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-524
Cell line databases/resources Cell_Model_Passport; SIDM01508
DSMZCellDive; ACC-524
Encyclopedic resources Wikidata; Q54830979
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
Polymorphism and mutation databases Cosmic; 2785208
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number19