Cellosaurus cell line PA333 (CVCL

Cellosaurus PA333 (CVCL_1G25)

Cross-references
Cell line name	PA333
Accession	CVCL_1G25
Resource Identification Initiative	To cite this cell line use: PA333 (RRID:CVCL_1G25)
Comments	Population: Japanese. Microsatellite instability: Stable (MSS) (PubMed=22156295). Omics: Genomics; Whole exome sequencing. Omics: Variations; SNP array analysis. Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=22156295). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=22156295). Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Ile435fs; Zygosity=Unspecified (PubMed=22156295). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Unspecified (PubMed=22156295).
Disease	Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=22156295; DOI=10.1101/gr.123109.111; PMCID=PMC3266029 Wang L.-H., Tsutsumi S., Kawaguchi T., Nagasaki K., Tatsuno K., Yamamoto S., Sang F., Sonoda K., Sugawara M., Saiura A., Hirono S., Yamaue H., Miki Y., Isomura M., Totoki Y., Nagae G., Isagawa T., Ueda H., Murayama-Hosokawa S., Shibata T., Sakamoto H., Kanai Y., Kaneda A., Noda T., Aburatani H. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res. 22:208-219(2012)
Cell line databases/resources	cancercelllines; CVCL_1G25
Encyclopedic resources	Wikidata; Q54937377
Polymorphism and mutation databases	Cosmic; 1820271
Entry history
Entry creation	08-Jul-2015
Last entry update	10-Apr-2025
Version number	13