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Cellosaurus KB-A1 (CVCL_1D82)

[Text version]
Cell line name KB-A1
Synonyms KB-A-1; KBA 1; KBA1
Accession CVCL_1D82
Resource Identification Initiative To cite this cell line use: KB-A1 (RRID:CVCL_1D82)
Comments Problematic cell line: Contaminated. Grand-parent cell line (KB) has been shown to be a HeLa derivative.
Population: African American.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2088 (KB-3-1)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line

PubMed=3711108; DOI=10.1016/S0021-9258(19)57466-X
Shen D.-W., Cardarelli C., Hwang J., Cornwell M., Richert N., Ishii S., Pastan I., Gottesman M.M.
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
J. Biol. Chem. 261:7762-7770(1986)

PubMed=15202936; DOI=10.1042/BA20040058
Ren Y.-H., Wei D.-Z., Zhan X.-Y.
Inhibition of P-glycoprotein and increasing of drug-sensitivity of a human carcinoma cell line (KB-A-1) by an antisense oligodeoxynucleotide-doxorubicin conjugate in vitro.
Biotechnol. Appl. Biochem. 41:137-143(2005)

Encyclopedic resources Wikidata; Q54899546
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number12