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Cellosaurus UM-Chor1 (CVCL_1D68)

[Text version]
Cell line name UM-Chor1
Synonyms UM-CHOR-1; UMCHOR1; University of Michigan-Chordoma-1
Accession CVCL_1D68
Resource Identification Initiative To cite this cell line use: UM-Chor1 (RRID:CVCL_1D68)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: ~5 days (PubMed=28430034); 5 days (Chordoma Foundation).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Bone, cranium, clivus; UBERON=UBERON_0004108.
HLA typing Source: Chordoma Foundation
Class I
HLA-AA*02,03
Disease Clivus chordoma (NCIt: C5412)
Chordoma (ORDO: Orphanet_178)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3270; PubMed=27102572

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133818,20
D3S135818
D5S8189,13
D7S82011
D8S117912,13
D13S31712
D16S53912
D18S5114
D19S43314,16
D21S1127,31
FGA19,23
Penta D8,9
Penta E7
TH017,9.3
TPOX8,9
vWA15

Run an STR similarity search on this cell line
Web pages Info; Chordoma Foundation; -; https://www.chordomafoundation.org/researchers/disease-models/um-chor1/
Publications

PubMed=27102572; DOI=10.1002/path.4729; PMCID=PMC4922416
Susanne Scheipl, Michelle Barnard, Lucia Cottone, Mette Jorgensen, David Harold Drewry, William J. Zuercher, Fabrice Turlais, Hong-Tao Ye, Ana P. Leite, James A. Smith, Andreas Leithner ...Show all 19 authors... , Peter Moller, Silke Bruderlein, Naomi Guppy, Fernanda Amary, Roberto Tirabosco, Sandra J. Strauss, Nischalan Pillay, Adrienne M. Flanagan; Show fewer authors
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J. Pathol. 239:320-334(2016)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Daniela Jager, Thomas F.E. Barth, Silke Bruderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, Andre Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 14 authors... , Christian R. Wirtz, Peter Moller, Kevin Mellert; Show fewer authors
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032-2032(2017)

PubMed=28430034; DOI=10.3171/2016.10.JNS16877; PMCID=PMC5650943
John Henry Owen, Christine M. Komarck, Anthony C. Wang, Waleed M. Abuzeid, Richard F. Keep, Erin L. McKean, Stephen Edwin Sullivan, Xing Fan, Mark Edward P. Prince;
UM-Chor1: establishment and characterization of the first validated clival chordoma cell line.
J. Neurosurg. 128:701-709(2018)

Cross-references
Cell line collections (Providers) ABM; T8149
ATCC; CRL-3270
Cell line databases/resources Cell_Model_Passport; SIDM01415
DepMap; ACH-001957
Encyclopedic resources Wikidata; Q54990767
Gene expression databases GEO; GSM2495967
GEO; GSM2495968
GEO; GSM2495969
Polymorphism and mutation databases Cosmic; 2663863
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number20