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Cellosaurus MCF-7/TAMR-4 (CVCL_1D42)

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Cell line name MCF-7/TAMR-4
Synonyms MCF7/TAMR-4; TAMR-4; TamR-4; TamR4
Accession CVCL_1D42
Resource Identification Initiative To cite this cell line use: MCF-7/TAMR-4 (RRID:CVCL_1D42)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): ECACC=16022528

Markers:
AmelogeninX
CSF1PO10
D3S135816
D5S81811,12
D7S8208,9
D8S117910,14
D13S31711
D16S53911,12
D18S5114
D21S1130
FGA23,25
Penta D12
Penta E7,12
TH016
TPOX9,12
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=16172194; DOI=10.1677/erc.1.00946
Thomas Frogne, Jan Stenvang Jepsen, Soren S. Larsen, Cathrine Kolster Fog, Bettina Lundin Brockdorff, Anne E. Lykkesfeldt;
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Endocr. Relat. Cancer 12:599-614(2005)

PubMed=25362855; DOI=10.1038/onc.2014.351
Susan Thrane, Astrid M. Pedersen, Mathilde Borg Houlberg Thomsen, Tove Kirkegaard, Birgitte Bruun Rasmussen, Anne Katrine Duun-Henriksen, Anne-Vibeke Laenkholm, Martin Bak, Anne E. Lykkesfeldt, Christina Westmose Yde;
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Oncogene 34:4199-4210(2015)

Cross-references
Cell line collections (Providers) CancerTools; 152088
ECACC; 16022528 - Discontinued
Ximbio; 152088
Cell line databases/resources cancercelllines; CVCL_1D42
Encyclopedic resources Wikidata; Q54904382
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number19