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Cellosaurus T47D/TR-1 (CVCL_1D36)

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Cell line name T47D/TR-1
Accession CVCL_1D36
Resource Identification Initiative To cite this cell line use: T47D/TR-1 (RRID:CVCL_1D36)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D45 (T47D/S2)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ECACC=16022513

Markers:
AmelogeninX
CSF1PO11,13
D5S81812
D7S82011
D8S117913
D13S31712
D16S53910
D18S5117
D21S1128,31
FGA23
Penta D10,12
Penta E7,14
TH016
TPOX11
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=25362855; DOI=10.1038/onc.2014.351
Susan Thrane, Astrid M. Pedersen, Mathilde Borg Houlberg Thomsen, Tove Kirkegaard, Birgitte Bruun Rasmussen, Anne Katrine Duun-Henriksen, Anne-Vibeke Laenkholm, Martin Bak, Anne E. Lykkesfeldt, Christina Westmose Yde;
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Oncogene 34:4199-4210(2015)

Cross-references
Cell line collections (Providers) CancerTools; 152108
ECACC; 16022513 - Discontinued
Ximbio; 152108
Cell line databases/resources cancercelllines; CVCL_1D36
Encyclopedic resources Wikidata; Q54971577
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number18