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Cellosaurus T47D/182R-2 (CVCL_1D35)

[Text version]
Cell line name T47D/182R-2
Synonyms T47D-182R2; 182R-2
Accession CVCL_1D35
Resource Identification Initiative To cite this cell line use: T47D/182R-2 (RRID:CVCL_1D35)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_31638; Fulvestrant (ICI 182780).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D46 (T47D/S5)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ECACC=16022508

Markers:
AmelogeninX
CSF1PO11,13
D3S135815,17
D5S81812
D7S82011
D8S117913
D13S31712
D16S53910
D18S5117
D21S1128,31
FGA23
Penta D10,12
Penta E7,14
TH016
TPOX11
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=24513268; DOI=10.1016/j.canlet.2013.10.014
Kirkegaard T., Hansen S.K., Larsen S.L., Reiter B.E., Sorensen B.S., Lykkesfeldt A.E.
T47D breast cancer cells switch from ER/HER to HER/c-Src signaling upon acquiring resistance to the antiestrogen fulvestrant.
Cancer Lett. 344:90-100(2014)

Cross-references
Cell line collections (Providers) CancerTools; 151890
ECACC; 16022508 - Discontinued
Ximbio; 151890
Cell line databases/resources cancercelllines; CVCL_1D35
Encyclopedic resources Wikidata; Q54971572
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number18