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Cellosaurus HROC46 T0 M1 (CVCL_1D21)

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Cell line name HROC46 T0 M1
Synonyms HROC46
Accession CVCL_1D21
Resource Identification Initiative To cite this cell line use: HROC46 T0 M1 (RRID:CVCL_1D21)
Comments From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
Population: Caucasian.
Characteristics: Established from a patient-derived xenograft established in female NOD SCID mice.
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A7UP ! B-LCL-HROC46
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811,13 (Direct_author_submission)
13 (PubMed=25926053)
D7S8208,11
D13S31712
D16S53912,13
D21S1128,32.2
TH016,9.3 (PubMed=25926053)
6,10 (Direct_author_submission)
TPOX8,11 (Direct_author_submission)
8,12 (PubMed=25926053)
vWA15,17

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Publications

PubMed=25309914; DOI=10.1155/2014/568693; PMCID=PMC4182691
Falko Lange, Benjamin Franz, Claudia Maletzki, Michael Linnebacher, Maja Huhns, Robert Jaster;
Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
BioMed Res. Int. 2014:568693.1-568693.13(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890
Christina Susanne Mullins, Bianca Micheel, Stephanie Matschos, Matthias Leuchter, Florian Burtin, Mathias Krohn, Maja Huhns, Ernst Klar, Friedrich Prall, Michael Linnebacher;
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references
Cell line collections (Providers) CLS; 300824
Encyclopedic resources Wikidata; Q54895296
Gene expression databases GEO; GSM1448084
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number18