Cellosaurus logo
expasy logo

Cellosaurus NF90-8 (CVCL_1B47)

[Text version]
Cell line name NF90-8
Synonyms MPNST 90-8TL; 90-8TL; NF190-8; 90-8
Accession CVCL_1B47
Resource Identification Initiative To cite this cell line use: NF90-8 (RRID:CVCL_1B47)
Comments Karyotypic information: Average ploidy of 3.56 (PubMed=36818284).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Left forearm; UBERON=UBERON_0002386.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34059954).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=34059954).
  • Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous; Note=Germline (PubMed=10534774).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Asp1302Tyrfs*5 (c.3904_3910del); Zygosity=Heterozygous; Note=Somatic (PubMed=36818284).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.96+1G>A (IVS3+1G>A); ClinVar=VCV000860797; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=7522538).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 17Y
Category Cancer cell line
STR profile Source(s): PubMed=32076030; PubMed=36818284

Markers:
AmelogeninX
CSF1PO12
D2S133816,24
D3S135815 (PubMed=36818284)
15,21 (PubMed=32076030)
D5S81811
D7S82011
D8S117910,12
D13S3178
D16S5399
D18S5114,18
D19S43313,16
D21S1130
FGA25
Penta D14
Penta E5,10
TH016
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=1568246; DOI=10.1016/0092-8674(92)90407-4
DeClue J.E., Papageorge A.G., Fletcher J.A., Diehl S.R., Ratner N., Vass W.C., Lowy D.R.
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis.
Cell 69:265-273(1992)

PubMed=7522538; DOI=10.1002/gcc.2870100405
Legius E., Dierick H., Wu R., Hall B.K., Marynen P., Cassiman J.-J., Glover T.W.
TP53 mutations are frequent in malignant NF1 tumors.
Genes Chromosomes Cancer 10:250-255(1994)

PubMed=10534774; DOI=10.1002/(SICI)1098-2264(199912)26:4<376::AID-GCC13>3.0.CO;2-O
Wu R., Lopez-Correa C., Rutkowski J.L., Baumbach-Reardon L.L., Glover T.W., Legius E.
Germline mutations in NF1 patients with malignancies.
Genes Chromosomes Cancer 26:376-380(1999)

PubMed=10791998; DOI=10.1172/JCI7610; PMCID=PMC315438
DeClue J.E., Heffelfinger S.C., Benvenuto G., Ling B., Li S.-W., Rui W., Vass W.C., Viskochil D., Ratner N.
Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models.
J. Clin. Invest. 105:1233-1241(2000)

PubMed=16239399; DOI=10.1124/jpet.105.091454
Mattingly R.R., Kraniak J.M., Dilworth J.T., Mathieu P., Bealmear B., Nowak J.E., Benjamins J.A., Tainsky M.A., Reiners J.J. Jr.
The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines.
J. Pharmacol. Exp. Ther. 316:456-465(2006)

PubMed=16510576; DOI=10.1158/0008-5472.CAN-05-3330
Miller S.J., Rangwala F., Williams J., Ackerman P., Kong S., Jegga A.G., Kaiser S., Aronow B.J., Frahm S., Kluwe L., Mautner V.-F., Upadhyaya M., Muir D.F. 4th, Wallace M.R., Hagen J., Quelle D.E., Watson M.A., Perry A., Gutmann D.H., Ratner N.
Large-scale molecular comparison of human Schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Cancer Res. 66:2584-2591(2006)

PubMed=21481793; DOI=10.1016/j.ccr.2011.02.017; PMCID=PMC3075552
Yi C.-L., Troutman S., Fera D., Stemmer-Rachamimov A.O., Avila J.L., Christian N., Persson N.L., Shimono A., Speicher D.W., Marmorstein R., Holmgren L., Kissil J.L.
A tight junction-associated merlin-angiomotin complex mediates merlin's regulation of mitogenic signaling and tumor suppressive functions.
Cancer Cell 19:527-540(2011)

PubMed=28469964; PMCID=PMC5411799
Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R., Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C., Field J.
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Am. J. Cancer Res. 7:923-934(2017)

PubMed=32076030; DOI=10.1038/s41598-020-59789-4; PMCID=PMC7031337
Amirnasr A., Verdijk R.M., van Kuijk P.F., Kartal P., Vriends A.L.M., French P.J., van Royen M.E., Taal W., Sleijfer S., Wiemer E.A.C.
Deregulated microRNAs in neurofibromatosis type 1 derived malignant peripheral nerve sheath tumors.
Sci. Rep. 10:2927.1-2927.14(2020)

PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054
Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:i50-i61(2020)

PubMed=34059954; DOI=10.1007/s00439-021-02296-x
Magallon-Lorenz M., Fernandez-Rodriguez J., Terribas E., Creus-Bachiller E., Romagosa C., Estival A., Perez Sidelnikova D., Salvador H., Villanueva A., Blanco I., Carrio M., Lazaro C., Serra E., Gel B.
Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation.
Hum. Genet. 140:1241-1252(2021)

PubMed=36818284; DOI=10.1016/j.isci.2023.106096; PMCID=PMC9929861
Magallon-Lorenz M., Terribas E., Ortega-Bertran S., Creus-Bachiller E., Fernandez M., Requena G., Rosas I., Mazuelas H., Uriarte-Arrazola I., Negro A., Lausova T., Castellanos E., Blanco I., DeVries G.H., Kawashima H., Legius E., Brems H., Mautner V.-F., Kluwe L., Ratner N., Wallace M.R., Fernandez-Rodriguez J., Lazaro C., Fletcher J.A., Reuss D.E., Carrio M., Gel B., Serra E.
Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
iScience 26:106096.1-106096.22(2023)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1B47
Encyclopedic resources Wikidata; Q54605631
Experimental variables resources EFO; EFO_0006288
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number16