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Cellosaurus FL (CVCL_1905)

[Text version]
Cell line name FL
Synonyms FL*; FL (HeLa derivative)
Accession CVCL_1905
Secondary accession CVCL_2900
Resource Identification Initiative To cite this cell line use: FL (RRID:CVCL_1905)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=1246601; PubMed=20143388). Originally thought to originate from a normal amnion.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00046.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Genomics; Whole genome sequencing; Low read coverage.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): ATCC=CCL-62; ECACC=90111910; IZSLER=BS CL 46

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135815,18
D5S81811,12
D7S8208,12
D8S117912,13
D13S31712,13.3 (ATCC=CCL-62)
12,14 (ECACC=90111910; IZSLER=BS CL 46)
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28 (IZSLER=BS CL 46)
27,28,29 (ATCC=CCL-62)
FGA18,21
Penta D8,15
Penta E17
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=13408317; DOI=10.3181/00379727-94-23003
Jorgen Fogh, Rosemary O. Lund;
Continuous cultivation of epithelial cell strain (FL) from human amniotic membrane.
Proc. Soc. Exp. Biol. Med. 94:532-537(1957)

PubMed=5668122; DOI=10.3181/00379727-128-33119
Ward Davis Peterson Jr., Cyril S. Stulberg, N.K. Swanborg, Andria Rasile Robinson;
Glucose-6-phosphate dehydrogenase isoenzymes in human cell cultures determined by sucrose-agar gel and cellulose acetate zymograms.
Proc. Soc. Exp. Biol. Med. 128:772-776(1968)

DOI=10.1007/BF02618370
Cyril S. Stulberg, Lewis Lemon Coriell, Alexis John Kniazeff, John E. Shannon;
The animal cell culture collection.
In Vitro 5:1-16(1970)

DOI=10.1007/978-1-4757-1647-4_13
June Lee Biedler;
Chromosome abnormalities in human tumor cells in culture.
(In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.359-394; Springer; New York; USA (1975)

PubMed=1246601; DOI=10.1126/science.1246601
Walter Anthony Nelson-Rees, Robert R. Flandermeyer;
HeLa cultures defined.
Science 191:96-98(1976)

PubMed=8397027
Hajime Ogura, Mitsuo Yoshinouchi, Takafumi Kudo, Makoto Imura, Tazuko Fujiwara, Yoshiro Yabe;
Human papillomavirus type 18 DNA in so-called HEP-2, KB and FL cells -- further evidence that these cells are HeLa cell derivatives.
Cell. Mol. Biol. 39:463-467(1993)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=23925245; DOI=10.1038/nature12064; PMCID=PMC3740412
Andrew C. Adey, Joshua N. Burton, Jacob O. Kitzman, Joseph B. Hiatt, Alexandra P. Lewis, Beth K. Martin, Ruo-Lan Qiu, Choli Lee, Jay Shendure;
The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line.
Nature 500:207-211(2013)

Cross-references
Cell line collections (Providers) ATCC; CCL-62
CCLV; CCLV-RIE 0012
ECACC; 90111910
IZSLER; BS CL 46
JCRB; JCRB9016 - Discontinued
Cell line databases/resources CLO; CLO_0003358
CLDB; cl1365
CLDB; cl1366
CLDB; cl1367
TOKU-E; 1269
Anatomy/cell type resources BTO; BTO_0003130
Biological sample resources BioSample; SAMN03151695
Encyclopedic resources Wikidata; Q54834949
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30