Cellosaurus cell line U-2940 (CVCL

Cellosaurus U-2940 (CVCL_1897)

[Text version]

Cell line name

U-2940

Synonyms

U2940

Accession

CVCL_1897

Resource Identification Initiative

To cite this cell line use: U-2940 (RRID:CVCL_1897)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Characteristics: Genetically heterogeneous, consists of 2 subclones (PubMed=27566572).
Doubling time: ~50 hours (DSMZ=ACC-634).
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Donor information: Originally the patient was suffering from Hodgkin lymphoma.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.

HLA typing

Source: DSMZCellDive=ACC-634

Class I
HLA-A	A*02:01:01,02:01:01
HLA-B	B*07:02:01,07:02:01
HLA-C	C*07:02:01,07:02:01
Class II
HLA-DP	DPA1*02:06,02:06
HLA-DQ	DQA1*01:02:01,01:02:01
	DQB1*06:02:01,06:02:01
HLA-DR	DRA*01:02:03,01:02:03
	DRB1*15:01:01,15:01:01

Disease

Diffuse large B-cell lymphoma (NCIt: C8851)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

18Y

Category

Cancer cell line

STR profile

Source(s): DSMZ=ACC-634

Markers:

Amelogenin	X
CSF1PO	12
D2S1338	19
D3S1358	16,17
D5S818	11,12
D7S820	10,12
D8S1179	12
D13S317	8,10
D16S539	10,12
D18S51	12,17
D19S433	14,15
D21S11	29
FGA	24,26
Penta D	14,15
Penta E	7,14
TH01	7,9.3
TPOX	8,12
vWA	17

Web pages

Info; MCLP; -; https://tcpaportal.org/mclp/

Publications

PubMed=16106419; DOI=10.1002/ijc.21417
Clara Sambade, Mattias Berglund, Svetlana Lagercrantz, Jan Sallstrom, Rui Manuel Reis, Gunilla Enblad, Bengt Glimelius, Christer Sundstrom;
U-2940, a human B-cell line derived from a diffuse large cell lymphoma sequential to Hodgkin lymphoma.
Int. J. Cancer 118:555-563(2006)

PubMed=27566572; DOI=10.18632/oncotarget.11524; PMCID=PMC5325377
Hilmar Quentmeier, Claudia Pommerenke, Ole Ammerpohl, Robert Geffers, Vivien Hauer, Roderick A.F. MacLeod, Stefan Nagel, Julia Romani, Emanuela Rosati, Anders Rosen, Cord C. Uphoff ...Show all 13 authors... , Margarete Zaborski, Hans Gunther Drexler; Show fewer authors
Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation.
Oncotarget 7:63456-63465(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Hans Gunther Drexler, Claudia Pommerenke, Sonja Eberth, Stefan Nagel;
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-634

Cell line databases/resources

cancercelllines; CVCL_1897
DepMap; ACH-001678
DSMZCellDive; ACC-634
Lonza; 1539

Biological sample resources

BioSample; SAMN03473453

Chemistry resources

ChEMBL-Cells; CHEMBL4523523
ChEMBL-Targets; CHEMBL4523554
PubChem_Cell_line; CVCL_1897

Encyclopedic resources

Wikidata; Q54973561

Gene expression databases

ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM1374972
GEO; GSM1897963

Polymorphism and mutation databases

Cosmic; 2437272
Cosmic; 2479246
Progenetix; CVCL_1897

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number