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Cellosaurus TOM-1 (CVCL_1895)

[Text version]
Cell line name TOM-1
Synonyms TOM1
Accession CVCL_1895
Resource Identification Initiative To cite this cell line use: TOM-1 (RRID:CVCL_1895)
Comments Population: Japanese.
Doubling time: ~60-70 hours (DSMZ=ACC-578).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C114819)
B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_585909)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-578

Markers:
AmelogeninX
CSF1PO10,11
D2S133818
D3S135816,17
D5S81811,13
D7S82010,12
D8S117913,14
D13S3178,11
D16S5399,10
D18S5113,15
D19S43314,15
D21S1131,33.2
FGA19,23
Penta D10,12
Penta E11,18
TH017,9
TPOX8,11
vWA17,18

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Publications

PubMed=3103721; DOI=10.1182/blood.V69.4.990.990
Mihiro Okabe, Shozo Matsushima, Masanobu Morioka, Masanobu Kobayashi, Shuichi Abe, Keisuke Sakurada, Mitsuaki Kakinuma, Tamotsu Miyazaki;
Establishment and characterization of a cell line, TOM-1, derived from a patient with Philadelphia chromosome-positive acute lymphocytic leukemia.
Blood 69:990-998(1987)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Armand Keating;
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=1884023; DOI=10.1182/blood.V78.6.1574.1574
Mihiro Okabe, Yasuyuki Kunieda, Toru Sugiwura, Masanori Tanaka, Takuto Miyagishima, Ikuo Saiki, Tomonori Minagawa, Mitsutoshi Kurosawa, Toshiyuki Itaya, Tamotsu Miyazaki;
Inhibitory effect of interleukin-4 on the in vitro growth of Ph1-positive acute lymphoblastic leukemia cells.
Blood 78:1574-1580(1991)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Cord C. Uphoff, Roderick A.F. MacLeod, Sabine A. Denkmann, Todd Robert Golub, Arndt Borkhardt, Johannes W.G. Janssen, Hans Gunther Drexler;
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Hans Gunther Drexler, Roderick A.F. MacLeod, Cord C. Uphoff;
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Cord C. Uphoff, Silke Habig, Severine Fombonne, Yoshinobu Matsuo, Hans Gunther Drexler;
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

Cross-references
Cell line collections (Providers) DSMZ; ACC-578
Cell line databases/resources DSMZCellDive; ACC-578
Biological sample resources BioSample; SAMN03473484
Encyclopedic resources Wikidata; Q54972778
Gene expression databases GEO; GSM236808
GEO; GSM236844
Polymorphism and mutation databases Cosmic; 1012125
Cosmic; 1026577
Cosmic; 1524825
Cosmic; 2491093
Cosmic; 2649234
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number25