Cellosaurus logo
expasy logo

Cellosaurus OCI-Ly7 (CVCL_1881)

[Text version]
Cell line name OCI-Ly7
Synonyms OCI-LY7; OCI-LY-7; OCI-Ly-7; Oci-Ly-7; OCI-Ly 7; OCI-Ly07; OCILY7; Ly7; LY7
Accession CVCL_1881
Resource Identification Initiative To cite this cell line use: OCI-Ly7 (RRID:CVCL_1881)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
From: Ontario Cancer Institute (OCI); Toronto; Canada.
Population: Caucasian.
Characteristics: Genetically heterogeneous, consists of 2 subclones (PubMed=27566572).
Doubling time: ~20-24 hours (DSMZ=ACC-688).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; ChIP-seq; H3K9ac.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*01:01
HLA-BB*13
HLA-CC*04:01
Class II
HLA-DQDQA1*05:02,05:02
DQB1*03:09,03:09
HLA-DRDRB1*13:03,07:01

Source: DSMZCellDive=ACC-688
Class I
HLA-AA*01:01:01,01:01:01
HLA-BB*35:02:01,35:02:01
HLA-CC*04:01:01,04:01:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*03:01:01,17:01
HLA-DQDQA1*05:05:01,05:05:01
DQB1*03:01:01,03:01:01
HLA-DRDRA*01:02:02,01:02:02
DRB1*13:03:01,13:03:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.44
Native American0.13
East Asian, North0
East Asian, South0.31
South Asian1.19
European, North69.58
European, South28.35
Disease Diffuse large B-cell lymphoma germinal center B-cell type (NCIt: C36080)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1659819; DepMap=ACH-001617; DSMZ=ACC-688

Markers:
AmelogeninX,Y
CSF1PO12,13
D2S133822,24
D3S135814,17
D5S81811,12
D7S82010
D8S117913,15
D13S31711,12
D16S53912,13
D18S5120
D19S43314,16
D21S1129,31.2
FGA20
Penta D11,13
Penta E11,12
TH016,9.3
TPOX8,12
vWA15,18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=3567358; DOI=10.1182/blood.V69.5.1307.1307
Mary Elizabeth Tweeddale, Bing Lim, Nazir Jamal, Jean Robinson, John Raymond Zalcberg, Gina Lockwood, Mark David Minden, Hans August Messner;
The presence of clonogenic cells in high-grade malignant lymphoma: a prognostic factor.
Blood 69:1307-1314(1987)

PubMed=8574164; DOI=10.3109/10428199509059672
Hong Chang, John A. Blondal, Sam Benchimol, Mark David Minden, Hans August Messner;
p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's lymphoma cell lines.
Leuk. Lymphoma 19:165-171(1995)

PubMed=11807979; DOI=10.1002/gcc.10025
Sukvarsha Mehra, Hans August Messner, Mark David Minden, Raju S.K. Chaganti;
Molecular cytogenetic characterization of non-Hodgkin lymphoma cell lines.
Genes Chromosomes Cancer 33:225-234(2002)

PubMed=15126345; DOI=10.1158/0008-5472.CAN-03-3773
Akinobu Ota, Hiroyuki Tagawa, Sivasundaram Karnan, Shinobu Tsuzuki, Abraham Karpas, Shigeki Kira, Yasuko Yoshida, Masao Seto;
Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.
Cancer Res. 64:3087-3095(2004)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028; PMCID=PMC3401058
Cheng Li, Sang-Woo Kim, Deepak Rai, Aswani R. Bolla, Siddharth Adhvaryu, Marsha C. Kinney, Ryan S. Robetorye, Ricardo C.T. Aguiar;
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

PubMed=19358282; DOI=10.1002/ijc.24351
Atsushi Inagaki, Takashi Ishida, Hiroki Yano, Toshihiko Ishii, Shigeru Kusumoto, Asahi Ito, Masaki Ri, Fumiko Mori, Jian-Min Ding, Hirokazu Komatsu, Shinsuke Iida, Ryuzo Ueda;
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=20054396; DOI=10.1038/nature08638; PMCID=PMC2845535
R. Eric Davis, Vu N. Ngo, Georg Lenz, Pavel Tolar, Ryan M. Young, Paul Bernard Romesser, Holger Kohlhammer, Laurence Lamy, Hong Zhao, Yan-Dan Yang, Wei-Hong Xu ...Show all 37 authors... , Arthur L. Shaffer 3rd, George Wright, Wen-Ming Xiao, John I. Powell, Jian-Kang Jiang, Craig J. Thomas, Andreas Rosenwald, German Ott, Hans-Konrad Muller-Hermelink, Randy D. Gascoyne, Joseph M. Connors, Nathalie A. Johnson, Lisa M. Rimsza, Elias Campo, Elaine Sarkin Jaffe, Wyndham H. Wilson, Jan Delabie, Erlend Bremertun Smeland, Richard I. Fisher, Rita Merle Braziel, Raymond Roy Tubbs, James R. Cook, Dennis D. Weisenburger, Wing-Chung Chan, Susan Keen Pierce, Louis Michael Staudt; Show fewer authors
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.
Nature 463:88-92(2010)

PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356
Michael Richard Green, Stefano Monti, Scott J. Rodig, Przemyslaw Juszczynski, Treeve Currie, Evan O'Donnell, Bjoern Chapuy, Kunihiko Takeyama, Donna Neuberg, Todd Robert Golub, Jeffery L. Kutok, Margaret Ann Shipp;
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)

PubMed=23257783; DOI=10.1038/leu.2012.367
Soren-Sebastian Wenzel, Michael Grau, Cory Mavis, Stephan Hailfinger, Annette Wolf, Hannelore Madle, George Deeb, Bernd Dorken, Margot Thome, Peter Lenz, Stefan Dirnhofer ...Show all 14 authors... , Francisco Javier Hernandez-Ilizaliturri, Alexandar Tzankov, Georg Lenz; Show fewer authors
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.
Leukemia 27:1381-1390(2013)

PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051
Jenny Zhang, Vladimir Grubor, Cassandra L. Love, Anjishnu Banerjee, Kristy L. Richards, Piotr Andrzej Mieczkowski, Cherie Dunphy, William Wai-Lap Choi, Wing Yan Au, Gopesh Srivastava, Patricia Lynne Lugar ...Show all 36 authors... , David A. Rizzieri, Anand S. Lagoo, Leon Bernal-Mizrachi, Karen P. Mann, Christopher Robert Flowers, Kikkeri N. Naresh, Andrew M. Evens, Leo I. Gordon, Magdalena B. Czader, Javed Iqbal Gill, Eric Darryl Hsi, Qing-Quan Liu, Alice Fan, Katherine Walsh, Dereje Jima, Lisa L. Smith, Amy J. Johnson, John C. Byrd, Micah Alan Luftig, Ting Ni, Jun Zhu, Amy Chadburn, Shawn Levy, David Brian Dunson, Sandeep S. Dave; Show fewer authors
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

PubMed=23699601; DOI=10.1182/blood-2013-02-483727; PMCID=PMC3744992
Ryan D. Morin, Karen Mungall, Erin D. Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, Jia-Rui Ding, Andrew Roth, Readman Chiu, Richard D. Corbett ...Show all 34 authors... , Fong Chun Chan, Maria Mendez-Lago, Diane L. Trinh, Madison Bolger-Munro, Greg Taylor, Alireza Hadj Khodabakhshi, Susana Ben-Neriah, Julia Pon, Barbara Meissner, Bruce W. Woolcock, Noushin Farnoud, Sanja Rogic, Emilia L. Lim, Nathalie A. Johnson, Sohrab P. Shah, Steven J.M. Jones, Christian Steidl, Robert A. Holt, Inanc Birol, Richard Moore, Joseph M. Connors, Randy D. Gascoyne, Marco Antonio Marra; Show fewer authors
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.
Blood 122:1256-1265(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27566572; DOI=10.18632/oncotarget.11524; PMCID=PMC5325377
Hilmar Quentmeier, Claudia Pommerenke, Ole Ammerpohl, Robert Geffers, Vivien Hauer, Roderick A.F. MacLeod, Stefan Nagel, Julia Romani, Emanuela Rosati, Anders Rosen, Cord C. Uphoff ...Show all 13 authors... , Margarete Zaborski, Hans Gunther Drexler; Show fewer authors
Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation.
Oncotarget 7:63456-63465(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-688
Cell line databases/resources cancercelllines; CVCL_1881
Cell_Model_Passport; SIDM00459
Cosmic-CLP; 1659819
DepMap; ACH-001617
DSMZCellDive; ACC-688
Anatomy/cell type resources BTO; BTO_0006414
Biological sample resources BioSample; SAMN03473439
ENCODE; ENCBS006VZG
ENCODE; ENCBS040MJM
ENCODE; ENCBS062JSC
ENCODE; ENCBS121JKZ
ENCODE; ENCBS141AMI
ENCODE; ENCBS182NFY
ENCODE; ENCBS304FAI
ENCODE; ENCBS581USS
ENCODE; ENCBS699NWP
ENCODE; ENCBS865AAA
ENCODE; ENCBS866AAA
ENCODE; ENCBS886BJZ
CRISP screens repositories BioGRID_ORCS_Cell_line; 1398
Chemistry resources ChEMBL-Cells; CHEMBL4523533
ChEMBL-Targets; CHEMBL4523564
GDSC; 1659819
PharmacoDB; OCILY7_1187_2019
PubChem_Cell_line; CVCL_1881
Encyclopedic resources Wikidata; Q54931777
Experimental variables resources EFO; EFO_0006711
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM380135
GEO; GSM552453
GEO; GSM562825
GEO; GSM1035333
GEO; GSM1059809
GEO; GSM1374789
Polymorphism and mutation databases Cosmic; 1329092
Cosmic; 1517649
Cosmic; 1541903
Cosmic; 1629934
Cosmic; 1945199
Cosmic; 2276331
Progenetix; CVCL_1881
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number43