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Cellosaurus NCEB-1 (CVCL_1875)

[Text version]
Cell line name NCEB-1
Synonyms Nceb-1; NCEB1; NCEB
Accession CVCL_1875
Resource Identification Initiative To cite this cell line use: NCEB-1 (RRID:CVCL_1875)
Comments Part of: Lymphoma Research Foundation Mantle Cell Lymphoma cell bank (LRF MCL cell bank).
Part of: MD Anderson Cell Lines Project.
Doubling time: 72-96 hours (PubMed=2848599); 19 hours (PubMed=25315077); ~50-70 hours (DSMZ=ACC-721).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Array-based CGH.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Caution: Established from a 57 year old male patient but contains some intact murine chromosomes (ATCC; PubMed=16448697) so should be considered as an hybrid cell line.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease Mantle cell lymphoma (NCIt: C4337)
Mantle cell lymphoma (ORDO: Orphanet_52416)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Category Hybrid cell line
STR profile Source(s): ATCC; DSMZ


Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/

PubMed=2848599; DOI=10.1182/blood.V72.6.2026.2026
Saltman D.L., Cachia P.G., Dewar A.E., Ross F.M., Krajewski A.S., Ludlam C., Steel C.M.
Characterization of a new non-Hodgkin's lymphoma cell line (NCEB-1) with a chromosomal (11:14) translocation [t(11:14)(q13;q32)].
Blood 72:2026-2030(1988)

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893
Stranks G., Height S.E., Mitchell P., Jadayel D.M., Yuille M.A.R., De Lord C., Clutterbuck R.D., Treleaven J.G., Powles R.L., Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., Millar J.L., Catovsky D., Dyer M.J.S.
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12169673; DOI=10.1016/S1525-1578(10)60693-9
Robetorye R.S., Bohling S.D., Morgan J.W., Fillmore G.C., Lim M.S., Elenitoba-Johnson K.S.J.
Microarray analysis of B-cell lymphoma cell lines with the t(14;18).
J. Mol. Diagn. 4:123-136(2002)

PubMed=16183118; DOI=10.1016/j.leukres.2005.08.016
Tucker C.A., Bebb G., Klasa R.J., Chhanabhai M., Lestou V.S., Horsman D.E., Gascoyne R.D., Wiestner A., Masin D., Bally M., Williams M.E.
Four human t(11;14)(q13;q32)-containing cell lines having classic and variant features of mantle cell lymphoma.
Leuk. Res. 30:449-457(2006)

PubMed=16448697; DOI=10.1016/j.leukres.2005.11.013
Camps J., Salaverria I., Garcia M.J., Prat E., Bea S., Pole J.C.M., Hernandez L., Del Rey J., Cigudosa J.C., Bernues M., Caldas C., Colomer D., Miro R., Campo E.
Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines.
Leuk. Res. 30:923-934(2006)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F., Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=25315077; DOI=10.3109/10428194.2014.970548
Fogli L.K., Williams M.E., Connors J.M., Reid Y.A., Brown K., O'Connor O.A.
Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection.
Leuk. Lymphoma 56:2114-2122(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cell line collections (Providers) ATCC; CRL-3005
Cell line databases/resources cancercelllines; CVCL_1875
DSMZCellDive; ACC-721
Biological sample resources BioSample; SAMN03471708
Encyclopedic resources Wikidata; Q54907697
Gene expression databases GEO; GSM95564
GEO; GSM95569
GEO; GSM104461
GEO; GSM115803
Polymorphism and mutation databases Cosmic; 1070711
Cosmic; 2296994
IARC_TP53; 25019
Progenetix; CVCL_1875
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number24