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Cellosaurus MUTZ-5 (CVCL_1873)

[Text version]
Cell line name MUTZ-5
Synonyms Mutz-5; MUTZ5; Menschliche Und Tierische Zellkulture-5
Accession CVCL_1873
Resource Identification Initiative To cite this cell line use: MUTZ-5 (RRID:CVCL_1873)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: ~70-100 hours (DOI=10.1007/978-3-642-59358-1_5; DSMZ=ACC-490).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*30:01,30:01
HLA-BB*13:02,13:02
HLA-CC*06:02,06:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African16.18
Native American0.51
East Asian, North0
East Asian, South2.27
South Asian12.13
European, North13.74
European, South55.18
Disease B acute lymphoblastic leukemia (NCIt: C8644)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L068 ! MUTZ-6
CVCL_L069 ! MUTZ-7
Sex of cell Male
Age at sampling 26Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-490

Markers:
AmelogeninX
CSF1PO8,9
D2S133819,21
D3S135815
D5S81811
D7S82010
D8S117910,11
D13S31710,12
D16S53910
D18S5114,15
D19S43314,17
D21S1129,31.2
FGA19,23
Penta D10,11
Penta E13,17
TH017
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=11516110; DOI=10.1038/sj.leu.2402212
Corinna Meyer, Roderick A.F. MacLeod, Hilmar Quentmeier, Johannes W.G. Janssen, Lionel Jean Andre Coignet, Martin John Swinnerton Dyer, Hans Gunther Drexler;
Establishment of the B cell precursor acute lymphoblastic leukemia cell line MUTZ-5 carrying a (12:13) translocation.
Leukemia 15:1471-1474(2001)

DOI=10.1007/978-3-642-59358-1_5
Corinna Meyer, Roderick A.F. MacLeod, Hilmar Quentmeier, Johannes W.G. Janssen, Lionel Jean Andre Coignet, Hans Gunther Drexler;
Establishment of the B-cell precursor-acute lymphoblastic leukemia cell line MUTZ-5 carrying a (12:13) translocation.
(In book chapter) Acute leukemias IX. Haematology and blood transfusion, Vol. 41; Hiddemann, Wolfgang & Haferlach, Torsten & Unterhalt, Michael & Buchner, Thomas & Ritter, Jorg (eds.); pp.15-18; Springer; Berlin; Germany (2003)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Anna K. Hagstrom-Andersson, Patrik Eden, David Lindgren, Jens Nilsson, Carin Lassen, Jesper Heldrup, Magnus Fontes, Ake Borg, Felix Mitelman, Bertil Johansson, Mattias Hoglund, Thoas Fioretos;
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-490
Cell line databases/resources cancercelllines; CVCL_1873
Cell_Model_Passport; SIDM01689
DepMap; ACH-000492
DSMZCellDive; ACC-490
Biological sample resources BioSample; SAMN03473564
BioSample; SAMN10988511
Chemistry resources PharmacoDB; MUTZ5_971_2019
Encyclopedic resources Wikidata; Q54907101
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887343
GEO; GSM888419
Polymorphism and mutation databases Cosmic; 1130257
Cosmic; 1278371
Cosmic; 1519165
Cosmic; 1524809
IARC_TP53; 30125
LiGeA; CCLE_431
Progenetix; CVCL_1873
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30