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Cellosaurus MUTZ-5 (CVCL_1873)

[Text version]
Cell line name MUTZ-5
Synonyms Mutz-5; MUTZ5; Menschliche Und Tierische Zellkulture-5
Accession CVCL_1873
Resource Identification Initiative To cite this cell line use: MUTZ-5 (RRID:CVCL_1873)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: ~70-100 hours (DOI=10.1007/978-3-642-59358-1_5; DSMZ=ACC-490).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*30:01,30:01
HLA-BB*13:02,13:02
HLA-CC*06:02,06:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African16.18
Native American0.51
East Asian, North0
East Asian, South2.27
South Asian12.13
European, North13.74
European, South55.18
Disease B acute lymphoblastic leukemia (NCIt: C8644)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L068 ! MUTZ-6
CVCL_L069 ! MUTZ-7
Sex of cell Male
Age at sampling 26Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-490

Markers:
AmelogeninX
CSF1PO8,9
D2S133819,21
D3S135815
D5S81811
D7S82010
D8S117910,11
D13S31710,12
D16S53910
D18S5114,15
D19S43314,17
D21S1129,31.2
FGA19,23
Penta D10,11
Penta E13,17
TH017
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=11516110; DOI=10.1038/sj.leu.2402212
Meyer C., MacLeod R.A.F., Quentmeier H., Janssen J.W.G., Coignet L.J.A., Dyer M.J.S., Drexler H.G.
Establishment of the B cell precursor acute lymphoblastic leukemia cell line MUTZ-5 carrying a (12:13) translocation.
Leukemia 15:1471-1474(2001)

DOI=10.1007/978-3-642-59358-1_5
Meyer C., MacLeod R.A.F., Quentmeier H., Janssen J.W.G., Coignet L.J.A., Drexler H.G.
Establishment of the B-cell precursor-acute lymphoblastic leukemia cell line MUTZ-5 carrying a (12:13) translocation.
(In) Acute leukemias IX. Haematology and blood transfusion, Vol. 41; Hiddemann W., Haferlach T., Unterhalt M., Buechner T., Ritter J. (eds.); pp.15-18; Springer; Berlin (2003)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:E0210404-E0210404(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-490
Cell line databases/resources cancercelllines; CVCL_1873
Cell_Model_Passport; SIDM01689
DepMap; ACH-000492
DSMZCellDive; ACC-490
Biological sample resources BioSample; SAMN03473564
BioSample; SAMN10988511
Chemistry resources PharmacoDB; MUTZ5_971_2019
Encyclopedic resources Wikidata; Q54907101
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887343
GEO; GSM888419
Polymorphism and mutation databases Cosmic; 1130257
Cosmic; 1278371
Cosmic; 1519165
Cosmic; 1524809
IARC_TP53; 30125
LiGeA; CCLE_431
Progenetix; CVCL_1873
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number29