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Cellosaurus MEC-2 (CVCL_1871)

[Text version]
Cell line name MEC-2
Synonyms MEC2
Accession CVCL_1871
Resource Identification Initiative To cite this cell line use: MEC-2 (RRID:CVCL_1871)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 31 hours (PubMed=10071128); ~40-50 hours (DSMZ=ACC-500).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; DNA methylation analysis.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.35
Native American0
East Asian, North2.58
East Asian, South0
South Asian5.1
European, North25.37
European, South65.6
Disease Chronic lymphocytic leukemia (NCIt: C3163)
B-cell chronic lymphocytic leukemia (ORDO: Orphanet_67038)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1870 ! MEC-1
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-500

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133816,19
D3S135815,19
D5S81810,12
D7S8207,11
D8S117913
D13S31711,12
D16S5399,11
D18S5114
D19S43312,14
D21S1127,29
FGA21,25
Penta D11,17
Penta E10,12
TH016,8
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=10071128; DOI=10.1016/S0145-2126(98)00154-4
Alessandra Stacchini, Michela Aragno, Antonella Vallario, Alda Alfarano, Paola Circosta, Daniela Gottardi, Alessandra Faldella, Giovanna Rege-Cambrin, Ulf Thunberg, Kenneth Nilsson, Federico Caligaris-Cappio;
MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation.
Leuk. Res. 23:127-136(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=19358282; DOI=10.1002/ijc.24351
Atsushi Inagaki, Takashi Ishida, Hiroki Yano, Toshihiko Ishii, Shigeru Kusumoto, Asahi Ito, Masaki Ri, Fumiko Mori, Jian-Min Ding, Hirokazu Komatsu, Shinsuke Iida, Ryuzo Ueda;
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168
Cord C. Uphoff, Sabine A. Denkmann, Klaus G. Steube, Hans Gunther Drexler;
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23297799; DOI=10.3109/10428194.2013.764418
Anna Lanemo Myhrinder, Eva Hellqvist, Ann-Charlotte Bergh, Mattias Jansson, Kenneth Nilsson, Per Hultman, Jon Jonasson, Anne Mette Buhl, Lone Bredo Pedersen, Jesper Jurlander, Eva Klein ...Show all 15 authors... , Nicole Weit, Marco Herling, Richard Rosenquist, Anders Rosen; Show fewer authors
Molecular characterization of neoplastic and normal 'sister' lymphoblastoid B-cell lines from chronic lymphocytic leukemia.
Leuk. Lymphoma 54:1769-1779(2013)

PubMed=25162594; DOI=10.1371/journal.pone.0106008; PMCID=PMC4146575
Eahsan Rasul, Daniel Salamon, Noemi Nagy, Benjamin Leveau, Ferenc Banati, Kalman Szenthe, Anita Koroknai, Janos Minarovits, George Klein, Eva Klein;
The MEC1 and MEC2 lines represent two CLL subclones in different stages of progression towards prolymphocytic leukemia.
PLoS ONE 9:e106008.1-e106008.8(2014)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-500
Cell line databases/resources CLO; CLO_0037182
cancercelllines; CVCL_1871
Cell_Model_Passport; SIDM00827
DepMap; ACH-001121
DSMZCellDive; ACC-500
LINCS_LDP; LCL-1090
Lonza; 1161
Anatomy/cell type resources BTO; BTO_0005914
Chemistry resources PharmacoDB; MEC2_912_2019
Encyclopedic resources Wikidata; Q54904996
Experimental variables resources EFO; EFO_0006285
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM887306
GEO; GSM888382
GEO; GSM1374668
GEO; GSM1670092
Polymorphism and mutation databases IARC_TP53; 30120
Progenetix; CVCL_1871
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number35