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Cellosaurus L-591 (CVCL_1867)

[Text version]
Cell line name L-591
Synonyms L 591; L591
Accession CVCL_1867
Resource Identification Initiative To cite this cell line use: L-591 (RRID:CVCL_1867)
Comments Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Virology: Contains a complete EBV genome (strain L591) which has been sequenced (PubMed=25787276).
Doubling time: ~72 hours (DSMZ=ACC-602).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Proteomics; Expression; Reverse-phase protein array.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Disease Hodgkin lymphoma (NCIt: C9357)
Hodgkin lymphoma (ORDO: Orphanet_98293)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 31Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-602

Markers:
AmelogeninX
CSF1PO10,11
D2S133817
D3S135815
D5S81811,12
D7S8209,13
D8S117912,13
D13S3177,13
D16S5399,12
D18S5112,19
D19S43312,16
D21S1129,30
FGA21,26
Penta D10,12
Penta E12,15
TH017,9.3
TPOX8,11
vWA16,21

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=6303739; DOI=10.1055/s-2008-1069671
Hartmut H. Kirchner, Heinz Burrichter, Harald Stein, Christa Fonatsch, Michael Schaadt, Andreas Ziegler, Wolfgang F.W. Heit, Volker Diehl;
Properties of Hodgkin cell lines. Possible significance for pathophysiology and clinical medicine.
Dtsch. Med. Wochenschr. 108:936-944(1983)

PubMed=6305805; DOI=10.1007/978-3-642-68761-7_81
Volker Diehl, Heinz Burrichter, Michael Schaadt, Hartmut H. Kirchner, Christa Fonatsch, Harald Stein, Johannes Gerdes, Wolfgang F.W. Heit, Andreas Ziegler;
Hodgkin's disease cell lines: characteristics and biological activities.
Haematol. Blood Transfus. 28:411-417(1983)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Michael Schaadt, Heinz Burrichter, Michael Pfreundschuh, Elizabeth Schell-Frederick, Hans Tesch, Christa Fonatsch, Harald Stein, Volker Diehl;
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

PubMed=12437638; DOI=10.1046/j.1365-2141.2002.03894.x
Martina Vockerodt, Gazanfer Belge, Dieter Kube, Johannes Irsch, Reiner Siebert, Hans Tesch, Volker Diehl, Jurgen Wolf, Jorn Bullerdiek, Andrea Berta Elisabeth Staratschek-Jox;
An unbalanced translocation involving chromosome 14 is the probable cause for loss of potentially functional rearranged immunoglobulin heavy chain genes in the Epstein-Barr virus-positive Hodgkin's lymphoma-derived cell line L591.
Br. J. Haematol. 119:640-646(2002)

PubMed=17065008; DOI=10.1080/10428190600667721
Alexander Feuerborn, Constanze Moritz, Frederike von Bonin, Matthias Dobbelstein, Lorenz Trumper, Benjamin Sturzenhofecker, Dieter Kube;
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.
Leuk. Lymphoma 47:1932-1940(2006)

PubMed=19380639; DOI=10.1084/jem.20090528; PMCID=PMC2715030
Roland Schmitz, Martin-Leo Hansmann, Verena Bohle, Jose Ignacio Martin-Subero, Sylvia Hartmann, Gunhild Mechtersheimer, Wolfram Klapper, Inga Vater, Maciej Giefing, Stefan Gesk, Jens Stanelle ...Show all 13 authors... , Reiner Siebert, Ralf Kuppers; Show fewer authors
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
J. Exp. Med. 206:981-989(2009)

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168
Cord C. Uphoff, Sabine A. Denkmann, Klaus G. Steube, Hans Gunther Drexler;
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=25787276; DOI=10.1128/JVI.03614-14; PMCID=PMC4442510
Anne L. Palser, Nicholas Edwin Grayson, Robert E. White, Craig Corton, Samantha Correia, Mohammed M. Ba Abdullah, Simon J. Watson, Matthew Cotten, John R. Arrand, Paul G. Murray, Martin John Allday ...Show all 15 authors... , Alan Bernard Rickinson, Lawrence S. Young, Paul J. Farrell, Paul Kellam; Show fewer authors
Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection.
J. Virol. 89:5222-5237(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Hans Gunther Drexler, Claudia Pommerenke, Sonja Eberth, Stefan Nagel;
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

Cross-references
Cell line collections (Providers) CLS; 300202
DSMZ; ACC-602
Cell line databases/resources DSMZCellDive; ACC-602
Biological sample resources BioSample; SAMN03473498
Encyclopedic resources Wikidata; Q54900877
Polymorphism and mutation databases Cosmic; 1289697
Cosmic; 1432038
Cosmic; 2464305
IARC_TP53; 23614
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25