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Cellosaurus BC-2 (CVCL_1856)

[Text version]
Cell line name BC-2
Synonyms BC2
Accession CVCL_1856
Resource Identification Initiative To cite this cell line use: BC-2 (RRID:CVCL_1856)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-2231.
Doubling time: ~50-70 hours (DSMZ=ACC-678).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
Omics: Array-based CGH.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Disease Primary effusion lymphoma (NCIt: C6915)
Primary effusion lymphoma (ORDO: Orphanet_48686)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 31Y
Category Cancer cell line
STR profile Source(s): ATCC; DSMZ

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133818,19
D3S135814,18
D5S81811,13
D7S8208,9
D8S117914,16
D13S31711,12
D16S53911,12
D18S5113,14
D19S43312,14
D21S1129,30
FGA22,24
Penta D10,13
Penta E13
TH017
TPOX10,11
vWA14,19

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=BC-2
https://cornell.flintbox.com/technologies/d21d6b39-b480-4ad4-8785-cc7a70c91788
Publications

PubMed=7670109; DOI=10.1182/blood.V86.7.2708.2708
Cesarman E., Moore P.S., Rao P.H., Inghirami G., Knowles D.M., Chang Y.
In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences.
Blood 86:2708-2714(1995)

PubMed=9766492; DOI=10.1038/sj.leu.2401160
Drexler H.G., Uphoff C.C., Gaidano G., Carbone A.
Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).
Leukemia 12:1507-1517(1998)

Patent=US5908773
Cesarman E., Arvanitakis L., Knowles D.M., Mesri E.A.
KSHV positive cell lines.
Patent number US5908773, 01-Jun-1999

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15613351; DOI=10.1128/JVI.79.2.1244-1251.2005
Fan W., Bubman D., Chadburn A., Harrington W.J. Jr., Cesarman E., Knowles D.M.
Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.
J. Virol. 79:1244-1251(2005)

PubMed=19608668; DOI=10.3324/haematol.2009.007260
Boulanger E., Marchio A., Hong S.-S., Pineau P.
Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin genes in human herpesvirus 8-associated primary effusion lymphoma.
Haematologica 94:1170-1174(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21685375; DOI=10.1182/blood-2010-12-323659
Roy D., Sin S.-H., Damania B., Dittmer D.P.
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood 118:E32-E39(2011)

Cross-references
Cell line collections (Providers) ATCC; CRL-2231
DSMZ; ACC-678
Cell line databases/resources CLO; CLO_0001889
cancercelllines; CVCL_1856
DSMZCellDive; ACC-678
IGRhCellID; BC2
LINCS_LDP; LCL-1957
Anatomy/cell type resources BTO; BTO:0002721
Biological sample resources BioSample; SAMN03471845
BioSamples; SAMEA365820
BioSamples; SAMEA365831
Chemistry resources GDSC; 1295743
PharmacoDB; BC2_78_2019
Encyclopedic resources Wikidata; Q54795187
Experimental variables resources EFO; EFO_0002045
Gene expression databases ArrayExpress; E-MTAB-38
GEO; GSM38794
GEO; GSM38795
GEO; GSM634732
GEO; GSM710418
GEO; GSM710434
Polymorphism and mutation databases Cosmic; 1238076
Cosmic; 1515187
Cosmic; 1588557
IARC_TP53; 26978
Progenetix; CVCL_1856
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number29