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Cellosaurus OACM5.1 C (CVCL_1842)

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Cell line name OACM5.1 C
Synonyms OAC-M5.1 C; OAC-M5.1; OACM5-1; OACM5.1; OACM5_1; OACM51
Accession CVCL_1842
Resource Identification Initiative To cite this cell line use: OACM5.1 C (RRID:CVCL_1842)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: ~48 hours (DSMZ=ACC-696).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.02
East Asian, North0
East Asian, South0
South Asian1.6
European, North72.08
European, South26.29
Disease Esophageal adenocarcinoma (NCIt: C4025)
Adenocarcinoma of the esophagus (ORDO: Orphanet_99976)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_JX13 (OACM5 1.C SC1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1503363; DSMZ=ACC-696; ECACC=11012006; PubMed=20075370

Markers:
AmelogeninX
CSF1PO10,13
D2S133819,24
D3S135816,17
D5S81811,12 (Cosmic-CLP=1503363; DSMZ=ACC-696; ECACC=11012006)
12 (PubMed=20075370)
D7S8208 (Cosmic-CLP=1503363; DSMZ=ACC-696; PubMed=20075370)
8.2 (ECACC=11012006)
D8S117913 (DSMZ=ACC-696)
13,14 (PubMed=20075370)
D13S31711,12
D16S53910,11
D18S5116
D19S43314,15
D21S1128,31
FGA22
Penta D10
Penta E7,14
TH016,9.3
TPOX8
vWA19,20

Run an STR similarity search on this cell line
Publications

PubMed=11407472; DOI=10.1007/s004280000358
Nico J. de Both, Bas P.L. Wijnhoven, Hein F.B.M. Sleddens, Hugo W. Tilanus, Winand N.M. Dinjens;
Establishment of cell lines from adenocarcinomas of the esophagus and gastric cardia growing in vivo and in vitro.
Virchows Arch. 438:451-456(2001)

PubMed=20075370; DOI=10.1093/jnci/djp499; PMCID=PMC2902814
Jurjen J. Boonstra, Ronald van Marion, David G. Beer, Lin Lin, Patricia Chaves, Catarina Ribeiro, A. Dias Pereira, Lucia Roque, S. Jane Darnton, Nasser Khaled Altorki, David S. Schrump ...Show all 19 authors... , David S. Klimstra, Laura H. Tang, James Richard Eshleman, Hector Alvarez, Yutaka Shimada, Herman van Dekken, Hugo W. Tilanus, Winand N.M. Dinjens; Show fewer authors
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Jurjen J. Boonstra, Hugo W. Tilanus, Winand N.M. Dinjens;
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27594985; DOI=10.12688/f1000research.7033.1; PMCID=PMC4991527
Gianmarco Contino, Matthew D. Eldridge, Maria Secrier, Lawrence Bower, Rachael Fels Elliott, Jamie Weaver, Andy G. Lynch, Paul A.W. Edwards, Rebecca Clare Fitzgerald;
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.
F1000Research 5:1336.1-1336.12(2016)

PubMed=28504813; DOI=10.3892/or.2017.5640; PMCID=PMC5492849
Elodie Melsens, Elly De Vlieghere, Benedicte Descamps, Christian Vanhove, Olivier De Wever, Wim Ceelen, Piet Pattyn;
Improved xenograft efficiency of esophageal adenocarcinoma cell lines through in vivo selection.
Oncol. Rep. 38:71-81(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-696
ECACC; 11012006
Cell line databases/resources cancercelllines; CVCL_1842
Cell_Model_Passport; SIDM00444
Cosmic-CLP; 1503363
DepMap; ACH-001368
DSMZCellDive; ACC-696
Biological sample resources BioSample; SAMN03473445
CRISP screens repositories BioGRID_ORCS_Cell_line; 970
Chemistry resources GDSC; 1503363
PharmacoDB; OACM51_1176_2019
Encyclopedic resources Wikidata; Q54931676
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670290
Polymorphism and mutation databases Cosmic; 1599344
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number33