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Cellosaurus NALM-20 (CVCL_1836)

[Text version]
Cell line name NALM-20
Synonyms NALM20
Accession CVCL_1836
Resource Identification Initiative To cite this cell line use: NALM-20 (RRID:CVCL_1836)
Comments Population: Japanese.
Doubling time: ~72 hours (PubMed=1817649); ~60-80 hours (DSMZ=ACC-681).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C114819)
B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_585909)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L054 ! B250
CVCL_1837 ! NALM-21
CVCL_5662 ! NALM-22
CVCL_5663 ! NALM-23
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-681; JCRB=JCRB1823

Markers:
AmelogeninX,Y
CSF1PO12
D2S133818,24
D3S135814,15
D5S81811,13
D7S82010,12
D8S117911,16
D13S3178,12
D16S5399,10
D18S5116,17
D19S43313,14
D21S1130,31.2
FGA20,21
Penta D11,13
Penta E9,18
TH019
TPOX8,11
vWA14,18

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Publications

PubMed=1817649
Yoshinobu Matsuo, Toshio Ariyasu, Eijiro Ohmoto, Ikuro Kimura, Jun Minowada;
Bi-phenotypic t(9;22)-positive leukemia cell lines from a patient with acute leukemia: NALM-20, established at the onset; and NALM-21, NALM-22 and NALM-23, established after relapse.
Hum. Cell 4:335-338(1991)

PubMed=8139288; DOI=10.1016/0145-2126(94)90118-x
Seitetsu Sato, Yoshio Honma, Motoo Hozumi, Yasuhide Hayashi, Yoshinobu Matsuo, Kiyoshi Shibata, Satoshi Omura, Ken-ichiro Hino, Shigeru Tomoyasu, Nobuyoshi Tsuruoka;
Effects of herbimycin A and its derivatives on growth and differentiation of Ph1-positive acute lymphoid leukemia cell lines.
Leuk. Res. 18:221-228(1994)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Yoshinobu Matsuo, Hans Gunther Drexler;
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Hans Gunther Drexler, Roderick A.F. MacLeod, Cord C. Uphoff;
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10233379; DOI=10.1111/j.1365-2141.1999.01284.x
F. Xu, Tomohiko Taki, Hong-Wei Yang, Ryoji Hanada, Teruaki Hongo, Hiroaki Ohnishi, Miyuki Kobayashi, Fumio Bessho, Masayoshi Yanagisawa, Yasuhide Hayashi;
Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children.
Br. J. Haematol. 105:155-162(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=14504097; DOI=10.1182/blood-2003-02-0418
Takeshi Taketani, Tomohiko Taki, Kanji Sugita, Yoshiyuki Furuichi, Eiichi Ishii, Ryoji Hanada, Masahiro Tsuchida, Kenichi Sugita, Kohmei Ida, Yasuhide Hayashi;
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)

PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001
Hilmar Quentmeier, Claudia Pommerenke, Hans Gunther Drexler;
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Curr. Issues Mol. Biol. 43:2147-2156(2021)

Cross-references
Cell line collections (Providers) DSMZ; ACC-681
JCRB; JCRB1823
Cell line databases/resources DSMZCellDive; ACC-681
Anatomy/cell type resources BTO; BTO_0004934
Biological sample resources BioSample; SAMN03473435
Encyclopedic resources Wikidata; Q54907401
Gene expression databases ArrayExpress; E-MTAB-11038
ArrayExpress; E-MTAB-11039
Polymorphism and mutation databases Cosmic; 996290
Cosmic; 998700
Cosmic; 999766
Cosmic; 1037714
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24