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Cellosaurus MEG-A2 (CVCL_1832)

[Text version]
Cell line name MEG-A2
Accession CVCL_1832
Resource Identification Initiative To cite this cell line use: MEG-A2 (RRID:CVCL_1832)
Comments Population: Japanese.
Doubling time: ~30 hours (PubMed=7869773); ~40 hours (DSMZ=ACC-718).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=7869773; PubMed=10071072; PubMed=10576511).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-718; JCRB=IFO50478

Markers:
AmelogeninX,Y
CSF1PO11,13
D2S133814,17
D3S135816
D5S81810,11
D7S82010,11
D8S117912
D13S3178,14
D16S53911,12
D18S5114,16
D19S43313,16
D21S1129
FGA21,22
Penta D12
Penta E12
TH016,7
TPOX8
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=7869773
Abe A., Emi N., Kato H., Adachi K., Murate T., Saga S., Ogura M., Kojima T., Tanimoto M., Morishita N., Kawashima K., Saito H.
Establishment and characterization of an immature human megakaryoblastic cell line, MEG-A2.
Leukemia 9:341-349(1995)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

Cross-references
Cell line collections (Providers) DSMZ; ACC-718
JCRB; IFO50478
Cell line databases/resources DSMZCellDive; ACC-718
Biological sample resources BioSample; SAMN03473398
Encyclopedic resources Wikidata; Q54905038
Polymorphism and mutation databases Cosmic; 1012086
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number21