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Cellosaurus LA-N-1 (CVCL_1827)

[Text version]
Cell line name LA-N-1
Synonyms LAN-1; LAN1; Lan1
Accession CVCL_1827
Resource Identification Initiative To cite this cell line use: LA-N-1 (RRID:CVCL_1827)
Comments Doubling time: ~100 hours (DSMZ=ACC-655); ~2 days (ECACC=06041201).
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2549 (LA1-5s)
Sex of cell Male
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): COG; DSMZ=ACC-655; ECACC=06041201; RCB=RCB0483

Markers:
AmelogeninX,Y
CSF1PO12
D2S133816,21
D3S135816,16.2
D5S81812
D7S82010 (COG)
10,11 (DSMZ=ACC-655; ECACC=06041201; RCB=RCB0483)
D8S117913,14
D13S31711,12
D16S5399
D18S5114
D19S43313
D21S1129,36
FGA19,24
Penta D9,13
Penta E11,12
TH018,9.3
TPOX8,11
vWA16,19

Run an STR similarity search on this cell line
Publications

PubMed=856461
Robert C. Seeger, Sylvia A. Rayner, Ashu Banerjee, Helen Chung, Walter E. Laug, Harry B. Neustein, William F. Benedict;
Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines.
Cancer Res. 37:1364-1371(1977)

PubMed=7037175
Charles Patrick Reynolds, Debra A. Reynolds, Eugene Philip Frenkel, R. Graham Smith;
Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.
Cancer Res. 42:1331-1336(1982)

DOI=10.1016/B978-0-12-008304-6.50015-4
June Lee Biedler, Marian B. Meyers, Barbara A. Spengler;
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff, Sergey & Hertz, Leif (eds.); pp.267-307; Academic Press; New York; USA (1983)

PubMed=2535691
Valentina C. Ciccarone, Barbara A. Spengler, Marian B. Meyers, June Lee Biedler, Robert A. Ross;
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

PubMed=7838528
Ngan Ching Cheng, Nadine Van Roy, Alvin Chan, Mabel Beitsma, Andries Westerveld, Frank Speleman, Rogier Versteeg;
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026
Hiroaki Komuro, Ryoko Saihara, Miki Shinya, Junko Takita, Setsuko Kaneko, Michio Kaneko, Yasuhide Hayashi;
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
J. Pediatr. Surg. 42:2040-2045(2007)

PubMed=18165268; DOI=10.2353/ajpath.2008.061263; PMCID=PMC2189624
Cornelia Stock, Eva Bozsaky, Franz Watzinger, Ulrike Poetschger, Lukas Orel, Thomas Lion, Agata Kowalska, Peter F. Ambros;
Genes proximal and distal to MYCN are highly expressed in human neuroblastoma as visualized by comparative expressed sequence hybridization.
Am. J. Pathol. 172:203-214(2008)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys ...Show all 22 authors... , Frank Speleman, Cecilia Kim, Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=18923523; DOI=10.1038/nature07398
Isabelle Janoueix-Lerosey, Delphine Lequin, Laurence Brugieres, Agnes Ribeiro, Loic de Pontual, Valerie Combaret, Virginie Raynal, Alain Puisieux, Gudrun Schleiermacher, Gaelle Pierron, Dominique Valteau-Couanet ...Show all 16 authors... , Thierry Frebourg, Jean Michon, Stanislas Lyonnet, Jeanne Amiel, Olivier Delattre; Show fewer authors
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
Nature 455:967-970(2008)

PubMed=18923524; DOI=10.1038/nature07399
Yu-Yan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Li-Li Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara ...Show all 14 authors... , Yasuhide Hayashi, Hiroyuki Mano, Seishi Ogawa; Show fewer authors
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20655465; DOI=10.1016/j.cell.2010.06.004; PMCID=PMC2913027
Michael Holzel, Si-Dong Huang, Jan Koster, Ingrid Ora, Arjan Lakeman, Huib Nicolaas Caron, Wouter Nijkamp, Jing Xie, Tom Callens, Shahab Asgharzadeh, Robert C. Seeger ...Show all 14 authors... , Ludwine M. Messiaen, Rogier Versteeg, Rene Bernards; Show fewer authors
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Joanna E. Gawecka, Dirk Geerts, Jan Koster, Maisel J. Caliva, Florian J. Sulzmaier, John Opoku-Ansah, Randal K. Wada, Andre S. Bachmann, Joe W. Ramos;
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

Cross-references
Cell line collections (Providers) DSMZ; ACC-655
ECACC; 06041201
ICLC; HTL98005 - Discontinued
RCB; RCB0483
Cell line databases/resources CLO; CLO_0007240
CLO; CLO_0051542
cancercelllines; CVCL_1827
DSMZCellDive; ACC-655
TOKU-E; 4118
Anatomy/cell type resources BTO; BTO_0003542
Biological sample resources BioSample; SAMN03472327
BioSample; SAMN03473468
Encyclopedic resources Wikidata; Q54901875
Experimental variables resources EFO; EFO_0005391
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM313802
GEO; GSM333797
GEO; GSM563355
GEO; GSM692872
GEO; GSM1366408
Polymorphism and mutation databases Cosmic; 801740
Cosmic; 920240
Cosmic; 947710
Cosmic; 1019927
Cosmic; 1037343
Cosmic; 1099140
Cosmic; 1109118
Cosmic; 1153781
Cosmic; 1153809
Cosmic; 1161991
Cosmic; 1167411
Cosmic; 1526627
Cosmic; 2131578
Cosmic; 2239461
Cosmic; 2301574
Cosmic; 2393635
Cosmic; 2485946
IARC_TP53; 21458
Progenetix; CVCL_1827
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number35