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Cellosaurus KG-1a (CVCL_1824)

[Text version]
Cell line name KG-1a
Synonyms KG-1A; KG1A; KG1a
Accession CVCL_1824
Resource Identification Initiative To cite this cell line use: KG-1a (RRID:CVCL_1824)
Comments Population: Caucasian.
Characteristics: Less differentiated subline of KG-1, composed of undifferentiated promyeloblasts.
Doubling time: ~45 hours (CLS=300234); ~50 hours (DSMZ=ACC-421).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:3688; FGFR1 + HGNC; HGNC:23098; FGFR1OP2; Name(s)=FGFR1OP2-FGFR1 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Disease Acute myeloid leukemia without maturation (NCIt: C3249)
Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0374 (KG-1)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-246.1; CCRID=1102HUM-NIFDC00028; CLS=300234; COG; DSMZ=ACC-421; ECACC=91030101; PubMed=11416159; PubMed=25877200; RCB=RCB1928; TKG=TKG 0402

Markers:
AmelogeninX,Y
CSF1PO7
D2S133820,23
D3S135815,16
D5S81813
D7S8208,10
D8S117913,14 (ATCC=CCL-246.1; CCRID=1102HUM-NIFDC00028; CLS=300234; DSMZ=ACC-421; PubMed=11416159; PubMed=25877200)
14 (COG)
D13S31711,12
D16S53910,11
D18S5110.2,18
D19S43311,16.2 (ATCC=CCL-246.1; COG)
11,17 (DSMZ=ACC-421)
16.2 (PubMed=25877200)
D21S1128,29
FGA22
Penta D8,9
Penta E7,13
TH017,8
TPOX7 (PubMed=25877200)
7,9 (ATCC=CCL-246.1; CCRID=1102HUM-NIFDC00028; CLS=300234; COG; DSMZ=ACC-421; ECACC=91030101; RCB=RCB1928; TKG=TKG 0402)
vWA14,19

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/description-of-normal-growth-and-morphology-of-atcc-ccl-246-1
Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=KG-1
Publications

PubMed=6967340; DOI=10.1182/blood.V56.2.265.265
Harold Phillip Koeffler, Ronald James Billing, Aldons Jake Lusis, Robert S. Sparkes, David W. Golde;
An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1).
Blood 56:265-273(1980)

PubMed=3094604; DOI=10.1182/blood.V68.5.1101.1101
Andrew John Watson Furley, Brian R. Reeves, Shuki Mizutani, Lynn J. Altass, Suzanne M. Watt, Michael C. Jacob, Peter van den Elsen, Cox Pieter Terhorst, Melvyn Francis Greaves;
Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines.
Blood 68:1101-1107(1986)

PubMed=8558913
S. Morita, S. Tsuchiya, Hiromi Fujie, Masayuki Itano, Yoshiyuki Ohashi, Masayoshi Minegishi, Masue Imaizumi, M. Endo, Nagako Takano, Tasuke Konno;
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=22844360; DOI=10.3892/ol.2012.709; PMCID=PMC3402744
Franca Pelliccia, Valentina Ubertini, Nazario Bosco;
The importance of molecular cytogenetic analysis prior to using cell lines in research: the case of the KG-1a leukemia cell line.
Oncol. Lett. 4:237-240(2012)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023)

Cross-references
Cell line collections (Providers) ATCC; CCL-246.1
BCRC; 60224
CLS; 300234
DSMZ; ACC-421
ECACC; 91030101
IZSLER; BS TCL 196
NCBI_Iran; C520
RCB; RCB1928
TKG; TKG 0402
Ubigene; YC-C083
Cell line databases/resources CLO; CLO_0007095
CLO; CLO_0051561
CLDB; cl3026
CLDB; cl3027
cancercelllines; CVCL_1824
CCRID; 1102HUM-NIFDC00028
DSMZCellDive; ACC-421
LINCS_LDP; LCL-1057
Lonza; 835
Anatomy/cell type resources BTO; BTO_0005076
Biological sample resources BioSample; SAMN01821644
BioSample; SAMN03470993
Chemistry resources ChEMBL-Cells; CHEMBL4295408
ChEMBL-Targets; CHEMBL4296453
PubChem_Cell_line; CVCL_1824
Encyclopedic resources Wikidata; Q54899835
Gene expression databases GEO; GSM1374598
GEO; GSM1446747
Polymorphism and mutation databases Cosmic; 787444
Cosmic; 821042
Cosmic; 850388
Cosmic; 985582
Cosmic; 994174
Cosmic; 1127254
Cosmic; 1319553
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number40