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Cellosaurus Karpas-231 (CVCL_1822)

[Text version]
Cell line name Karpas-231
Synonyms KARPAS-231; Karpas 231; KARPAS 231; KARPAS231; K231
Accession CVCL_1822
Resource Identification Initiative To cite this cell line use: Karpas-231 (RRID:CVCL_1822)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: ~30-40 hours (DSMZ=ACC-562); ~60 hours (ECACC=06120601).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Miscellaneous: Originally assigned to be from a B-cell acute lymphoblastic leukemia (ALL-L3).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North1.09
East Asian, South0
South Asian0.51
European, North68.07
European, South30.33
Disease Diffuse large B-cell lymphoma (NCIt: C8851)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1327774; DSMZ=ACC-562

Markers:
AmelogeninX
CSF1PO11,14
D2S133818,23
D3S135815,17
D5S81812
D7S8208,9
D8S117910,12
D13S3178,12
D16S53911,13
D18S5115,17
D19S43314,15
D21S1127,31.2
FGA20
Penta D12,14
Penta E7,14
TH018,9.3
TPOX8,9
vWA18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=8324225; DOI=10.1182/blood.V82.1.231.bloodjournal821231
Elisabeth Nacheva, Martin John Swinnerton Dyer, Patricia E. Fischer, Gail Stranks, Julie M. Heward, Robert E. Marcus, Colin Grace, Abraham Karpas;
C-MYC translocations in de novo B-cell lineage acute leukemias with t(14;18) (cell lines Karpas 231 and 353).
Blood 82:231-240(1993)

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893
Gail Stranks, Susan E. Height, Paul Mitchell, Dalal Mouneimne Jadayel, Martin A.R. Yuille, Corinne F.M. De Lord, Robyn D. Clutterbuck, Jennie G. Treleaven, Ray Leonard Powles, Elisabeth Nacheva, David G. Oscier, Abraham Karpas, Gilbert Marcel Lenoir ...Show all 17 authors... , Stephen D. Smith, John L. Millar, Daniel Catovsky, Martin John Swinnerton Dyer; Show fewer authors
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

PubMed=8574789
Sylvie Galiegue-Zouitina, Sabine Quief, Marie-Paule Hildebrand, Claude Denis, Gerard Lecocq, Maude Collyn-d'Hooghe, Christian Bastard, Martin A.R. Yuille, Martin John Swinnerton Dyer, Jean-Pierre Kerckaert;
Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3;11) (q27;q23) chromosomal translocation.
C. R. Acad. Sci. III, Sci. Vie 318:1125-1131(1995)

PubMed=8618432
Sylvie Galiegue-Zouitina, Sabine Quief, Marie-Paule Hildebrand, Claude Denis, Gerard Lecocq, Maude Collyn-d'Hooghe, Christian Bastard, Martin A.R. Yuille, Martin John Swinnerton Dyer, Jean-Pierre Kerckaert;
The B cell transcriptional coactivator BOB1/OBF1 gene fuses to the LAZ3/BCL6 gene by t(3;11)(q27;q23.1) chromosomal translocation in a B cell leukemia line (Karpas 231).
Leukemia 10:579-587(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Cinta Mestre-Escorihuela, Fanny Rubio-Moscardo, Jose A. Richter, Reiner Siebert, Joan Climent, Vicente Fresquet, Elena Beltran, Xabier Agirre, Isabel Marugan, Miguel Marin, Andreas Rosenwald, Kei-ji Sugimoto, Luise M. Wheat ...Show all 21 authors... , E. Loraine Karran, Juan Fernando Garcia Garcia, Lydia Sanchez-Verde, Felipe Prosper, Louis Michael Staudt, Daniel Pinkel, Martin John Swinnerton Dyer, Jose Angel Martinez-Climent; Show fewer authors
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=26727417; DOI=10.3109/10428194.2015.1108414
Hans Gunther Drexler, Sonja Eberth, Stefan Nagel, Roderick A.F. MacLeod;
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Leuk. Lymphoma 57:1015-1020(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers, Michael A. Davies, Wan-Leng Deng ...Show all 25 authors... , Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-562 - Discontinued
ECACC; 06120601
Cell line databases/resources CLO; CLO_0037175
cancercelllines; CVCL_1822
Cell_Model_Passport; SIDM01017
Cosmic-CLP; 1327774
DepMap; ACH-002255
DSMZCellDive; ACC-562
LINCS_LDP; LCL-1087
Biological sample resources BioSample; SAMN03473540
Chemistry resources GDSC; 1327774
PharmacoDB; KARPAS231_728_2019
Encyclopedic resources Wikidata; Q54899491
Experimental variables resources EFO; EFO_0005389
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM115820
GEO; GSM1035318
GEO; GSM1374586
GEO; GSM1374587
GEO; GSM1669974
Polymorphism and mutation databases Cosmic; 1281371
Cosmic; 2297008
Progenetix; CVCL_1822
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number36