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Cellosaurus VAL (CVCL_1819)

[Text version]
Cell line name VAL
Accession CVCL_1819
Resource Identification Initiative To cite this cell line use: VAL (RRID:CVCL_1819)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: ~50-70 hours (DSMZ=ACC-586).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Miscellaneous: Originally assigned to be from a B-cell acute lymphoblastic leukemia.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
HLA typing Source: DSMZCellDive=ACC-586
Class I
HLA-AA*02:01:01,68:01:01
HLA-BB*15:01:01,15:01:01
HLA-CC*03:03:01,03:03:01
Class II
HLA-DPDPA1*02:02:02,02:01:02
DPB1*19:01,19:01
HLA-DQDQA1*01:03:01,01:03:01
DQB1*06:03:01,06:03:01
HLA-DRDRA*01:01:01,01:01:01
DRB1*13:01:01,13:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North0
East Asian, South0.47
South Asian2.83
European, North64.59
European, South32.11
Disease Diffuse large B-cell lymphoma (NCIt: C8851)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1331048; DepMap=ACH-001703; DSMZ=ACC-586

Markers:
AmelogeninX
CSF1PO10,12
D2S133820,23
D3S135817,19
D5S81811
D7S82010
D8S117911,12
D13S31710,14
D16S5399,13
D18S5114,16,17 (DSMZ=ACC-586)
16,17 (DepMap=ACH-001703)
D19S43313,14
D21S1127,30
FGA22,24
Penta D9
Penta E7
TH016,9
TPOX8
vWA14,15

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=8220427; DOI=10.1038/ng0993-66
Jean-Pierre Kerckaert, Clotilde Deweindt, Herve Tilly, Sabine Quief, Gerard Lecocq, Christian Bastard;
LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.
Nat. Genet. 5:66-70(1993)

PubMed=8558920
Wilhelm Gerhard Dirks, Margarete Zaborski, Kathrin Jager, Cecile Challier, Mami Shiota, Hilmar Quentmeier, Hans Gunther Drexler;
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Cinta Mestre-Escorihuela, Fanny Rubio-Moscardo, Jose A. Richter, Reiner Siebert, Joan Climent, Vicente Fresquet, Elena Beltran, Xabier Agirre, Isabel Marugan, Miguel Marin, Andreas Rosenwald ...Show all 21 authors... , Kei-ji Sugimoto, Luise M. Wheat, E. Loraine Karran, Juan Fernando Garcia Garcia, Lydia Sanchez-Verde, Felipe Prosper, Louis Michael Staudt, Daniel Pinkel, Martin John Swinnerton Dyer, Jose Angel Martinez-Climent; Show fewer authors
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=19358282; DOI=10.1002/ijc.24351
Atsushi Inagaki, Takashi Ishida, Hiroki Yano, Toshihiko Ishii, Shigeru Kusumoto, Asahi Ito, Masaki Ri, Fumiko Mori, Jian-Min Ding, Hirokazu Komatsu, Shinsuke Iida, Ryuzo Ueda;
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168
Cord C. Uphoff, Sabine A. Denkmann, Klaus G. Steube, Hans Gunther Drexler;
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=26727417; DOI=10.3109/10428194.2015.1108414
Hans Gunther Drexler, Sonja Eberth, Stefan Nagel, Roderick A.F. MacLeod;
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Leuk. Lymphoma 57:1015-1020(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-586
Cell line databases/resources CLO; CLO_0037067
cancercelllines; CVCL_1819
Cell_Model_Passport; SIDM00416
Cosmic-CLP; 1331048
DepMap; ACH-001703
DSMZCellDive; ACC-586
LINCS_LDP; LCL-1915
Lonza; 1237
Biological sample resources BioSample; SAMN03473489
Chemistry resources GDSC; 1331048
PharmacoDB; VAL_1652_2019
Encyclopedic resources Wikidata; Q54992842
Experimental variables resources EFO; EFO_0022344
Gene expression databases ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM115973
GEO; GSM201349
GEO; GSM1035309
GEO; GSM1670570
Polymorphism and mutation databases Cosmic; 1086346
Cosmic; 1517631
Cosmic; 1541908
Cosmic; 2276320
Cosmic; 2297002
Cosmic; 2590022
Progenetix; CVCL_1819
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number38