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Cellosaurus AP-1060 (CVCL_1807)

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Cell line name AP-1060
Accession CVCL_1807
Resource Identification Initiative To cite this cell line use: AP-1060 (RRID:CVCL_1807)
Comments Doubling time: ~48 hours (PubMed=15116119); ~80-100 hours (DSMZ=ACC-593).
Omics: Variations; Array-based CGH.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene deletion; HGNC; HGNC:12796; WT1; Zygosity=Homozygous (PubMed=29119387).
  • Gene fusion; HGNC; HGNC:3495; ETV6 + HGNC; HGNC:8033; NTRK3; Name(s)=ETV6-NTRK3, TEL-TRKC (PubMed=29119387).
  • Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (PubMed=15116119).
  • Mutation; HGNC; HGNC:9864; RARA; Simple; p.Pro408Ser (c.1222C>T); Zygosity=Unspecified; Note=Equivalent to p.Pro900Ser in the PML-RARA fusion protein (PubMed=15116119).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-593

Markers:
AmelogeninX,Y
CSF1PO12
D2S133817,23
D3S135814,16
D5S81812
D7S82010,11
D8S117912
D13S3178,12
D16S53910,11
D18S5114,19
D19S43314
D21S1129,32.2
FGA19,24
Penta D9,13
Penta E5,12
TH019.3
TPOX8,11
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=15116119; DOI=10.1038/sj.leu.2403372
Yi Sun, Soon H. Kim, Da-Cheng Zhou, Wei Ding, Elisabeth M. Paietta, Fabien Guidez, Artur Zelent, K.H. Ramesh, Linda A. Cannizzaro, Raymond P. Warrell Jr., Robert E. Gallagher;
Acute promyelocytic leukemia cell line AP-1060 established as a cytokine-dependent culture from a patient clinically resistant to all-trans retinoic acid and arsenic trioxide.
Leukemia 18:1258-1269(2004)

PubMed=29119387; DOI=10.1007/s13402-017-0356-2
Su-Ning Chen, Stefan Nagel, Bjorn Schneider, Hai-Ping Dai, Robert Geffers, Maren Kaufmann, Corinna Meyer, Claudia Pommerenke, Kenneth S. Thress, Jiao Li, Hilmar Quentmeier ...Show all 13 authors... , Hans Gunther Drexler, Roderick A.F. MacLeod; Show fewer authors
A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target -- a short report.
Cell. Oncol. (Dordr.) 41:93-101(2018)

PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680
Rafal Skopek, Malgorzata Palusinska, Katarzyna Kaczor-Keller, Rafal Pingwara, Anna Papierniak-Wygladala, Tino Schenk, Slawomir Lewicki, Artur Zelent, Lukasz Szymanski;
Choosing the right cell line for acute myeloid leukemia (AML) research.
Int. J. Mol. Sci. 24:5377.1-5377.34(2023)

Cross-references
Cell line collections (Providers) DSMZ; ACC-593
Cell line databases/resources DSMZCellDive; ACC-593
Biological sample resources BioSample; SAMN03473492
Encyclopedic resources Wikidata; Q54750179
Polymorphism and mutation databases Cosmic; 2750857
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number26