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Cellosaurus AMO1 (CVCL_1806)

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Cell line name AMO1
Synonyms AMo1; AMO-1
Accession CVCL_1806
Resource Identification Initiative To cite this cell line use: AMO1 (RRID:CVCL_1806)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Characteristics: Produces IgA kappa.
Doubling time: ~24 hours (PubMed=8426482); ~70-90 hours (DSMZ=ACC-538).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck, Catherine.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Gene fusion; HGNC; HGNC:5719; IGKJ1 + HGNC; HGNC:5743; IGKV1-8; Name(s)=IGKV1-8-IGKJ1 (CelloPub=CLPUB00604).
  • Gene fusion; HGNC; HGNC:5720; IGKJ2 + HGNC; HGNC:5817; IGKV3-20; Name(s)=IGKV3-20-IGKJ2 (CelloPub=CLPUB00604).
  • Mutation; HGNC; HGNC:20893; BCOR; Simple; p.Gln312del (c.932_934AGC[1]) (c.935_937delAGC); ClinVar=VCV000418060; Zygosity=Heterozygous (Cosmic-CLP=1295741).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala146Thr (c.436G>A); ClinVar=VCV000197243; Zygosity=Heterozygous (Cosmic-CLP=1295741; DepMap=ACH-000838).
  • Mutation; HGNC; HGNC:11364; STAT3; Simple; p.Cys712Tyr (c.2135G>A); Zygosity=Heterozygous (Cosmic-CLP=1295741; DepMap=ACH-000838).
  • Mutation; HGNC; HGNC:25941; TET2; Simple; p.Gln1699Ter (c.5095C>T); Zygosity=Heterozygous (Cosmic-CLP=1295741; DepMap=ACH-000838).
HLA typing Source: Direct_author_submission
Class I
HLA-AA*26:03,33
HLA-BB*44,54:01
HLA-CC*01:02/03,14:02/03

Source: PubMed=26589293
Class I
HLA-AA*26:03,33:03
HLA-BB*44:03,54:01
HLA-CC*14:03,14:03
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.35
Native American0
East Asian, North79.12
East Asian, South17.86
South Asian0
European, North0
European, South1.66
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): CCRID=1101HUM-PUMC000683; Cosmic-CLP=1295741; DSMZ=ACC-538; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D2S133819
D3S135815,18
D5S81812
D6S104311,19
D7S8209,11
D8S117913,15
D12S39117,19
D13S3178
D16S5399,13
D18S5115,18
D19S43315.2 (CCRID=1101HUM-PUMC000683)
16 (DSMZ=ACC-538)
D21S1130,33.2
FGA19,24
Penta D9,15
Penta E11
TH017,9
TPOX8 (PubMed=25877200)
8,9 (CCRID=1101HUM-PUMC000683; Cosmic-CLP=1295741; DSMZ=ACC-538)
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=8426482
Shiro Shimizu, Tomoo Takiguchi, Masaaki Fukutoku, Ritsuko Yoshioka, Yuko Hirose, Shiro Fukuhara, Hitoshi Ohno, Yoshiaki Isobe, Susumu Konda;
Establishment of a CD4-positive plasmacytoma cell line (AMO1).
Leukemia 7:274-280(1993)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

DOI=10.1007/0-306-46877-8_4
Helena Jernberg-Wiklund, Kenneth Nilsson;
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11429052; DOI=10.1111/j.1349-7006.2001.tb01142.x; PMCID=PMC5926752
Ichiro Hanamura, Shinsuke Iida, Yumiko Akano, Yoshihito Hayami, Miyuki Kato, Kazuhisa Miura, Shinsuke Harada, Shogo Banno, Atsushi Wakita, Hitoshi Kiyoi, Tomoki Naoe, Shiro Shimizu, Shin-ichi Sonta ...Show all 16 authors... , Masakazu Nitta, Masafumi Taniwaki, Ryuzo Ueda; Show fewer authors
Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations.
Jpn. J. Cancer Res. 92:638-644(2001)

PubMed=12886255; DOI=10.1038/sj.leu.2403026
Yoshihito Hayami, S. Iida, Naozo Nakazawa, Ichiro Hanamura, M. Kato, H. Komatsu, Ikuo Miura, Bhavana J. Dave, Warren G. Sanger, B. Lim, Masafumi Taniwaki, R. Ueda;
Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma.
Leukemia 17:1650-1657(2003)

PubMed=15215163; DOI=10.1016/S0002-9440(10)63276-2; PMCID=PMC1618545
Jun Inoue, Takemi Otsuki, Akira Hirasawa, Issei Imoto, Yoshinobu Matsuo, Shiroh Shimizu, Masafumi Taniwaki, Johji Inazawa;
Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.
Am. J. Pathol. 165:71-81(2004)

PubMed=17171682; DOI=10.1002/gcc.20404
Luigia Lombardi, Giulia Poretti, Michela Mattioli, Sonia Fabris, Luca Agnelli, Silvio Bicciato, Ivo Kwee, Andrea Rinaldi, Domenica Ronchetti, Donata Verdelli, Giorgio Lambertenghi-Deliliers, Francesco Bertoni, Antonino Neri; Show fewer authors ...Show all 13 authors...
Molecular characterization of human multiple myeloma cell lines by integrative genomics: insights into the biology of the disease.
Genes Chromosomes Cancer 46:226-238(2007)

PubMed=18700954; DOI=10.1186/1755-8794-1-37; PMCID=PMC2531129
Domenica Ronchetti, Marta Lionetti, Laura Mosca, Luca Agnelli, Adrian Andronache, Sonia Fabris, Giorgio Lambertenghi-Deliliers, Antonino Neri;
An integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma.
BMC Med. Genomics 1:37.1-37.9(2008)

PubMed=19306352; DOI=10.1002/gcc.20660
Marta Lionetti, Luca Agnelli, Laura Mosca, Sonia Fabris, Adrian Andronache, Katia Todoerti, Domenica Ronchetti, Giorgio Lambertenghi-Deliliers, Antonino Neri;
Integrative high-resolution microarray analysis of human myeloma cell lines reveals deregulated miRNA expression associated with allelic imbalances and gene expression profiles.
Genes Chromosomes Cancer 48:521-531(2009)

PubMed=21173094; DOI=10.3324/haematol.2010.033456; PMCID=PMC3069235
Jerome Moreaux, Bernard Klein, Francois-Regis Bataille, Geraldine Descamps, Sophie Maiga, Dirk Hose, Hartmut Goldschmidt, Anna Jauch, Thierry Reme, Michel Jourdan, Martine Amiot, Catherine Pellat-Deceunynck;
A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines.
Haematologica 96:574-582(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy, Manway Liu, Lauren Murray ...Show all 61 authors... , Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau, Jens Reeder, Yi Cao ...Show all 30 authors... , Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25688540; DOI=10.1002/cyto.a.22643
Sophie Maiga, Carole Brosseau, Geraldine Descamps, Christelle Dousset, Patricia Gomez-Bougie, David Chiron, Emmanuelle Menoret, Charlotte Kervoelen, Henri Vie, Anne Cesbron, Agnes Moreau-Aubry, Martine Amiot, Catherine Pellat-Deceunynck; Show fewer authors ...Show all 13 authors...
A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
Cytometry A 87:285-288(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

CLPUB00604
Sharon Chow;
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers, Michael A. Davies, Wan-Leng Deng ...Show all 25 authors... , Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda, De-Chen Lin, Henry He Yang ...Show all 14 authors... , Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30545397; DOI=10.1186/s13045-018-0679-0; PMCID=PMC6293660
Benoit Tessoulin, Agnes Moreau-Aubry, Geraldine Descamps, Patricia Gomez-Bougie, Sophie Maiga, Alban Gaignard, David Chiron, Emmanuelle Menoret, Steven Le Gouill, Philippe Moreau, Martine Amiot, Catherine Pellat-Deceunynck;
Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.
J. Hematol. Oncol. 11:137.1-137.13(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu, Alexander Y. Andreev-Drakhlin, Jaegil Kim ...Show all 68 authors... , Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Vishesh Sarin, Katharine Yu, Ian D. Ferguson, Olivia Gugliemini, Matthew A. Nix, Byron Hann, Marina Sirota, Arun P. Wiita;
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-538
IBRC; C10685
Cell line databases/resources CLO; CLO_0037047
cancercelllines; CVCL_1806
CCRID; 1101HUM-PUMC000683
Cell_Model_Passport; SIDM00993
CGH-DB; 9156-4
Cosmic-CLP; 1295741
DepMap; ACH-000838
DSMZCellDive; ACC-538
LINCS_LDP; LCL-1539
Biological sample resources BioSample; SAMN03472930
BioSample; SAMN03473529
BioSample; SAMN10989573
Chemistry resources ChEMBL-Cells; CHEMBL4523527
ChEMBL-Targets; CHEMBL4523558
GDSC; 1295741
PharmacoDB; AMO1_62_2019
PubChem_Cell_line; CVCL_1806
Encyclopedic resources Wikidata; Q54749810
Experimental variables resources EFO; EFO_0006534
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-TABM-1088
GEO; GSM143353
GEO; GSM290285
GEO; GSM562822
GEO; GSM886868
GEO; GSM887933
GEO; GSM1374392
GEO; GSM1669599
Polymorphism and mutation databases Cosmic; 1483074
Cosmic; 1889514
Cosmic; 2131561
Cosmic; 2391800
Cosmic; 2809758
IARC_TP53; 28503
LiGeA; CCLE_604
Progenetix; CVCL_1806
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number43