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Cellosaurus YT (CVCL_1797)

[Text version]
Cell line name YT
Synonyms YT-0
Accession CVCL_1797
Resource Identification Initiative To cite this cell line use: YT (RRID:CVCL_1797)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Population: Japanese.
Doubling time: ~40-50 hours (DSMZ=ACC-434).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pericardial effusion; UBERON=UBERON_0002409.
Cell type: Natural killer cell; CL=CL_0000623.
HLA typing Source: DSMZCellDive=ACC-434
Class I
HLA-AA*26:01:01,31:01:02
HLA-BB*48:01:01,48:01:01
HLA-CC*01:02:01,08:01:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*02:01:02,02:01:02
HLA-DQDQA1*01:02:01,01:04:01
DQB1*05:03:01,06:02:01
HLA-DRDRA*01:01:01,01:01:01
DRB1*14:54:01,15:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.12
Native American0.69
East Asian, North74.01
East Asian, South25.17
South Asian0
European, North0
European, South0
Disease Natural killer cell lymphoblastic leukemia/lymphoma (NCIt: C82217)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A1JN (YT clone 2C2)CVCL_EJ05 (YT-1)CVCL_A1JP (YTC3)
CVCL_D324 (YTS)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=946358; DSMZ=ACC-434

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133819,20
D3S135815,17
D5S81810,11
D7S82011,12
D8S117913,16
D13S3179,11
D16S53910,12
D18S5114,16
D19S43314,15
D21S1130,32
FGA22,23
Penta D10,11
Penta E15
TH016,7
TPOX8
vWA17,18,20 (DSMZ=ACC-434)
17,20 (Cosmic-CLP=946358)

Run an STR similarity search on this cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=YT
Publications

PubMed=2578514; DOI=10.4049/jimmunol.134.3.1623
Junji Yodoi, Keisuke Teshigawara, Toshio Nikaido, Kiyoshi Fukui, Takahumi Noma, Tasuku Honjo, Masahiro Takigawa, Masao S. Sasaki, Nagahiro Minato, Mitsuru Tsudo, Takashi Uchiyama, Michiyuki Maeda;
TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells).
J. Immunol. 134:1623-1630(1985)

PubMed=3098894; DOI=10.1084/jem.165.1.223; PMCID=PMC2188268
Keisuke Teshigawara, Huey-Mei Wang, Koichi Kato, Kendall Arthur Smith;
Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.
J. Exp. Med. 165:223-238(1987)

PubMed=1313126
Noriko Yoneda, Eiji Tatsumi, Seiji Kawano, Keisuke Teshigawara, Tatsushi Oka, Minoru Fukuda, Nobuo Yamaguchi;
Detection of Epstein-Barr virus genome in natural-killer-like cell line, YT.
Leukemia 6:136-141(1992)

PubMed=9787181; DOI=10.1182/blood.V92.9.3410
Akira Sakai, Catherine Thieblemont, Axel Wellmann, Elaine Sarkin Jaffe, Mark Raffeld;
PTEN gene alterations in lymphoid neoplasms.
Blood 92:3410-3415(1998)

PubMed=10803505; DOI=10.1038/sj.leu.2401778
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma.
Leukemia 14:777-782(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x; PMCID=PMC11159954
Angen Liu, Tetsuya Takakuwa, Wen-Juan Luo, Shigeki Fujita, Katsuyuki Aozasa;
Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection.
Cancer Sci. 97:605-610(2006)

PubMed=19194464; DOI=10.1038/leu.2009.3
Javeed Iqbal, Can Kucuk, Ronald J. Deleeuw, Gopesh Srivastava, Wayne Tam, Hui-Min Geng, David L. Klinkebiel, Judith K. Christman, Kavita N. Patel, K. Cao, L. Shen ...Show all 18 authors... , Karen Dybkaer, Ivy F.L. Tsui, Hesham H. Ali, N. Shimizu, Wing Yan Au, Wan L. Lam, Wing-Chung Chan; Show fewer authors
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
Leukemia 23:1139-1151(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168
Cord C. Uphoff, Sabine A. Denkmann, Klaus G. Steube, Hans Gunther Drexler;
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=21052088; DOI=10.1038/leu.2010.255
Javeed Iqbal, Dennis D. Weisenburger, Aparajita Chowdhury, Ming-Ying Tsai, Gopesh Srivastava, Timothy Charles Greiner, Can Kucuk, Karen E. Deffenbacher, Julie Marie Vose, L. Smith, Wing Yan Au ...Show all 22 authors... , Shigeo Nakamura, Masao Seto, Jan Delabie, Francoise Berger, Florence Loong, Young-Hyeh Ko, Ivy Sng, X. Liu, Thomas P. Loughran Jr., James Olen Armitage, Wing-Chung Chan; Show fewer authors
International Peripheral T-cell Lymphoma Project
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro.
Leukemia 25:348-358(2011)

PubMed=25586472; DOI=10.1038/ncomms7025; PMCID=PMC7743911
Can Kucuk, Bei Jiang, Xiao-Zhou Hu, Wen-Yan Zhang, John K.C. Chan, Wen-Ming Xiao, Nathan Lack, Can Alkan, John C. Williams, Kendra N. Avery, Pynar Kavak ...Show all 28 authors... , Anna Scuto, Emel Sen, Philippe Gaulard, Louis Michael Staudt, Javeed Iqbal, Wei-Wei Zhang, Adam Cornish, Qiang Gong, Qun-Pei Yang, Hong Sun, Francesco Annibale d'Amore, Sirpa Leppa, Wei-Ping Liu, Kai Fu, Laurence de Leval, Timothy W. McKeithan, Wing-Chung Chan; Show fewer authors
Activating mutations of STAT5B and STAT3 in lymphomas derived from gammadelta-T or NK cells.
Nat. Commun. 6:6025.1-6025.12(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-434
Cell line databases/resources CLO; CLO_0009718
Cell_Model_Passport; SIDM00410
Cosmic-CLP; 946358
DepMap; ACH-002317
DSMZCellDive; ACC-434
LINCS_LDP; LCL-1913
Anatomy/cell type resources BTO; BTO_0005228
Biological sample resources BioSample; SAMN03473541
Chemistry resources ChEMBL-Cells; CHEMBL3308146
ChEMBL-Targets; CHEMBL2366114
GDSC; 946358
PharmacoDB; YT_1688_2019
PubChem_Cell_line; CVCL_1797
Encyclopedic resources Wikidata; Q54995532
Experimental variables resources EFO; EFO_0022423
Gene expression databases ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM236811
GEO; GSM236847
GEO; GSM472010
GEO; GSM1670588
Polymorphism and mutation databases Cosmic; 850219
Cosmic; 946358
Cosmic; 991546
Cosmic; 1012130
Cosmic; 1524828
Cosmic; 1542072
Cosmic; 2390120
Cosmic; 2785211
IARC_TP53; 27711
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37