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Cellosaurus WERI-Rb-1 (CVCL_1792)

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Cell line name WERI-Rb-1
Synonyms WERI-RB-1; WERI-Rb 1; WERI-Rb1; WERI-RB1; WERI Rb-1; WERIRb1; WERI; Wills Eye Research Institute-Retinoblastoma-1
Accession CVCL_1792
Secondary accession CVCL_2757
Resource Identification Initiative To cite this cell line use: WERI-Rb-1 (RRID:CVCL_1792)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Doubling time: 96 hours (PubMed=844036); 50 hours (PubMed=25326674); 84 hours (PubMed=31781967); ~49 hours (DSMZ=ACC-90).
Omics: Genomics; ChIP-seq; CTCF.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Eye, globe; UBERON=UBERON_0010230.
Sequence variations
Disease Retinoblastoma (NCIt: C7541)
Retinoblastoma (ORDO: Orphanet_790)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B7IE (WERI-Rb-1 CDDP-R)CVCL_B7ID (WERI-Rb-1 Eto-R)
Sex of cell Female
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-169; DepMap=ACH-001421; DSMZ=ACC-90; JCRB=JCRB3028; RCB=RCB2146; TKG=TKG 0601

Markers:
AmelogeninX
CSF1PO10 (TKG=TKG 0601)
10,12,13 (ATCC=HTB-169; DepMap=ACH-001421; DSMZ=ACC-90; RCB=RCB2146)
11,12 (JCRB=JCRB3028)
D2S133812,15
D3S135814,15
D5S81811,12
D7S82010,12,13 (JCRB=JCRB3028)
10,13 (ATCC=HTB-169; DepMap=ACH-001421; DSMZ=ACC-90; RCB=RCB2146; TKG=TKG 0601)
D8S117912,15
D13S31714
D16S53913
D18S5113,19
D19S43314,15
D21S1129
FGA21
Penta D12,13
Penta E7,11
TH019.3
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/WERI-Rb-1_Stam_protocol.pdf
Publications

PubMed=844036
Rosemary C. McFall, Theodore W. Sery, Marcia Makadon;
Characterization of a new continuous cell line derived from a human retinoblastoma.
Cancer Res. 37:1003-1010(1977)

PubMed=679190
Rosemary C. McFall, Rose Marie Nagy, Barbara T. Nagle, Loily M. McGreevy;
Scanning electron microscopic observation of two retinoblastoma cell lines.
Cancer Res. 38:2827-2835(1978)

PubMed=6351622; DOI=10.1016/S0002-9394(14)77822-5
Yuichi Ohashi, Tetsuo Sasabe, Teruo Nishida, Yasuaki Nishi, Hideyoshi Higashi;
Hanganutziu-Deicher heterophile antigen in human retinoblastoma cells.
Am. J. Ophthalmol. 96:321-325(1983)

DOI=10.5795/jjscc.24.451
Masaru Tsumuraya, Takashi Nakajima, Takeo Terasaki, Tetsuro Kodama, Yukio Shimosato, Hisaaki Higuchi, Yoshio Uei;
Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.
Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985)

PubMed=2751270
Helen S.L. Chan, Marc D. Canton, Brenda Louise Gallie;
Chemosensitivity and multidrug resistance to antineoplastic drugs in retinoblastoma cell lines.
Anticancer Res. 9:469-474(1989)

PubMed=1682862; DOI=10.1016/S0161-6420(91)32134-1
Helen S.L. Chan, Paul Scott Thorner, George Haddad, Brenda Louise Gallie;
Multidrug-resistant phenotype in retinoblastoma correlates with P-glycoprotein expression.
Ophthalmology 98:1425-1431(1991)

PubMed=7689221; DOI=10.1073/pnas.90.16.7578; PMCID=PMC47185
Roseline Godbout, Jeremy Andrew Squire;
Amplification of a DEAD box protein gene in retinoblastoma cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:7578-7582(1993)

PubMed=7499444; DOI=10.1007/BF01213319
Motoko Inomata, Nagahiro Saijo, Kazuko Kawashima, Akihiro Kaneko, Yasuhiro Fujiwara, Hiroshi Kunikane, Yasuhiko Tanaka;
Induction of apoptosis in cultured retinoblastoma cells by the protein phosphatase inhibitor, okadaic acid.
J. Cancer Res. Clin. Oncol. 121:729-738(1995)

PubMed=19686387; DOI=10.1111/j.1471-4159.2009.06322.x; PMCID=PMC3726384
Darryl D. Glubrecht, Ji-Hyeon Kim, Laurie Russell, John Stephen Bamforth, Roseline Godbout;
Differential CRX and OTX2 expression in human retina and retinoblastoma.
J. Neurochem. 111:250-263(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23498719; DOI=10.1016/S1470-2045(13)70045-7
Diane E. Rushlow, Berber M. Mol, Jennifer Y. Kennett, Stephanie Yee, Sanja Pajovic, Brigitte L. Theriault, Nadia L. Prigoda-Lee, Clarellen Spencer, Helen Dimaras, Timothy W. Corson, Renee Pang ...Show all 25 authors... , Christine Massey, Roseline Godbout, Zhe Jiang, Eldad Zacksenhaus, Katherine Paton, Annette C. Moll, Claude Houdayer, Anthony Raizis, William Halliday, Wan L. Lam, Paul Christopher Boutros, Dietmar R. Lohmann, Josephine C. Dorsman, Brenda Louise Gallie; Show fewer authors
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.
Lancet Oncol. 14:327-334(2013)

PubMed=25326674; DOI=10.1007/s00418-014-1285-z
Maike Anna Busch, Claudia Philippeit, Andreas Weise, Nicole Dunker;
Re-characterization of established human retinoblastoma cell lines.
Histochem. Cell Biol. 143:325-338(2015)

PubMed=27115612; DOI=10.1371/journal.pone.0153323; PMCID=PMC4846005
Irsan E. Kooi, Berber M. Mol, Maarten P.G. Massink, Marcus C. de Jong, Pim de Graaf, Paul van der Valk, Hanne Meijers-Heijboer, Gertjan J.L. Kaspers, Annette C. Moll, Hein te Riele, Jacqueline Cloos, Josephine C. Dorsman;
A meta-analysis of retinoblastoma copy numbers refines the list of possible driver genes involved in tumor progression.
PLoS ONE 11:e0153323.1-e0153323.20(2016)

PubMed=28713896; DOI=10.3892/ijmm.2017.3058; PMCID=PMC5547939
Ying Liu, Zhi-Gang Fan, Kang Li, Fei Deng, Yun-Fan Xiong, Mei-Xin Liang, Jian Ge;
An optimized gene transfection system in WERI-Rb1 cells.
Int. J. Mol. Med. 40:801-813(2017)

PubMed=29192327; DOI=10.3892/or.2017.6100; PMCID=PMC5783599
Maike Anna Busch, David Papior, Harald Stephan, Nicole Dunker;
Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell lines.
Oncol. Rep. 39:160-172(2018)

PubMed=30584916; DOI=10.1016/j.yexcr.2018.12.018
Melanie Schwermer, Michaela Hiber, Sabine Dreesmann, Anja Rieb, Jessica Theissen, Thomas Herold, Alexander Schramm, Petra Temming, Laura Steenpass;
Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines.
Exp. Cell Res. 375:92-99(2019)

PubMed=31781967; DOI=10.1007/s00418-019-01832-1
Hemanth Ravishankar, Abubakar Siddiq Mangani, M. Bhavani Shankar, Mayur Joshi, Thiyagarajan Devasena, Sowmya Parameswaran, Krishnakumar Subramaniam;
Characterization of NCC-RbC-51, an RB cell line isolated from a metastatic site.
Histochem. Cell Biol. 153:101-109(2020)

PubMed=32123578; DOI=10.1038/s41420-020-0237-8; PMCID=PMC7026052
Arthur Aubry, Tao Yu, Rod Bremner;
Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy.
Cell Death Discov. 6:2.1-2.12(2020)

PubMed=35409416; DOI=10.3390/ijms23074058; PMCID=PMC9000009
Vinodh Kakkassery, Timo Gemoll, Miriam M. Kraemer, Thorben Sauer, Aysegul Tura, Mahdy Ranjbar, Salvatore Grisanti, Stephanie C. Joachim, Stefan Mergler, Jacqueline Reinhard;
Protein profiling of WERI-RB1 and etoposide-resistant WERI-ETOR reveals new insights into topoisomerase inhibitor resistance in retinoblastoma.
Int. J. Mol. Sci. 23:4058.1-4058.14(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0029002/4899
ATCC; HTB-169
CLS; 300632
DSMZ; ACC-90
ECACC; 06070602
IZSLER; BS TCL 231
JCRB; JCRB3028
JCRB; KURB2683 - Discontinued
RCB; RCB2146
TKG; TKG 0601
Cell line databases/resources CLO; CLO_0009583
CLO; CLO_0009584
CLO; CLO_0051563
CLDB; cl4695
cancercelllines; CVCL_1792
CCRID; 3101HUMTCHu213
Cell_Model_Passport; SIDM01414
DepMap; ACH-001421
DSMZCellDive; ACC-90
IGRhCellID; WERIRb1
Lonza; 1147
Biological sample resources BioSample; SAMN03472730
ENCODE; ENCBS087YAE
ENCODE; ENCBS270AAA
ENCODE; ENCBS282DQM
ENCODE; ENCBS283KOW
ENCODE; ENCBS283WND
ENCODE; ENCBS679NMZ
Encyclopedic resources Wikidata; Q54993776
Experimental variables resources EFO; EFO_0005715
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
GEO; GSM749679
GEO; GSM749766
GEO; GSM749768
GEO; GSM824870
GEO; GSM945263
GEO; GSM945318
GEO; GSM1486290
GEO; GSM2043881
Polymorphism and mutation databases Cosmic; 688119
Cosmic; 909782
Progenetix; CVCL_1792
Proteomic databases PRIDE; PXD030924
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number38