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Cellosaurus TGBC24TKB (CVCL_1770)

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Cell line name TGBC24TKB
Synonyms TGBC-24-TKB; YoMi
Accession CVCL_1770
Resource Identification Initiative To cite this cell line use: TGBC24TKB (RRID:CVCL_1770)
Comments Part of: Biliary tract cancer cell line atlas.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys242Alafs*5 (c.723delC) (p.S241fs); ClinVar=VCV001074338; Zygosity=Homozygous (Cosmic-CLP=910695; DepMap=ACH-002312).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North75.8
East Asian, South23.94
South Asian0
European, North0.26
European, South0
Disease Gallbladder carcinoma (NCIt: C3844)
Carcinoma of gallbladder and extrahepatic biliary tract (ORDO: Orphanet_56044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=910695; RCB=RCB1196

Markers:
AmelogeninX
CSF1PO12,13
D5S81811
D7S82010,11
D13S31712
D16S5399,10
TH016
TPOX8
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=21451941; DOI=10.1007/s00534-011-0376-7
Jun Sato, Takashi Kimura, Takuro Saito, Takayuki Anazawa, Akira Kenjo, Yoshihiro Sato, Takao Tsuchiya, Mitsukazu Gotoh;
Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma.
J. Hepatobiliary Pancreat. Sci. 18:700-711(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=32899426; DOI=10.3390/cancers12092510; PMCID=PMC7565451
Dominique Scherer, Marcela Davila-Lopez, Benjamin Goeppert, Sanna Abrahamsson, Rosa Gonzalez Silos, Igor Nova, Katherine Marcelain, Juan Carlos Roa, David Ibberson, Sinan U. Umu, Trine Ballestad Rounge ...Show all 13 authors... , Stephanie Roessler, Justo Lorenzo-Bermejo; Show fewer authors
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Cancers (Basel) 12:2510.1-2510.14(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448
Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, Prabhat Kattel, Lauren Kenney, Joshua Merritt, Ramzi Adil, Qi-Biao Wu, Yuan-Li Zhen ...Show all 39 authors... , Robert Morris, Johannes Kreuzer, Meena Kathiresan, Xcanda Ixchel Herrera Lopez, Haley Ellis, Ilaria G. Gritti, Lilian Lecorgne, Ines Farag, Alexandra Popa, William Shen, Hiroyuki Kato, Qin Xu, Eranga Roshan Balasooriya, Meng-Ju Wu, Saireudee Chaturantabut, Robin Kate Kelley, James Mark Cleary, Michael Scott Lawrence, David E. Root, Cyril Henri Benes, Vikram Deshpande, Dejan Juric, William Raj Sellers, Cristina Rosa Ferrone, Wilhelm Haas, Francisca Vazquez, Gad Getz, Nabeel M. Bardeesy; Show fewer authors
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
bioRxiv 2024:07.04.601970-07.04.601970(2024)

Cross-references
Cell line collections (Providers) RCB; RCB1196
Cell line databases/resources CLO; CLO_0050018
cancercelllines; CVCL_1770
Cell_Model_Passport; SIDM00267
Cosmic-CLP; 910695
DepMap; ACH-002312
LINCS_LDP; LCL-1344
Biological sample resources BioSample; SAMN03472177
Chemistry resources ChEMBL-Cells; CHEMBL3308856
ChEMBL-Targets; CHEMBL2366093
GDSC; 910695
PharmacoDB; TGBC24TKB_1591_2019
PubChem_Cell_line; CVCL_1770
Encyclopedic resources Wikidata; Q54972239
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670541
Polymorphism and mutation databases Cosmic; 910695
Cosmic; 2629285
IARC_TP53; 27262
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39